Application of Adipose-Derived Stem Cells in Heart Disease

被引：44

作者：

Chen, Lina ^{[1
]}

Qin, Fengming ^{[1
]}

Ge, Menghua ^{[1
]}

Shu, Qiang ^{[2
]}

Xu, Jianguo ^{[1
,3
,4
]}

机构：

[1] Shaoxing Second Hosp, Shaoxing, Zhejiang, Peoples R China

[2] Zhejiang Univ, Childrens Hosp, Shaoxing 312000, Zhejiang, Peoples R China

[3] Zhejiang Univ, Affiliated Hosp 1, Shaoxing 312000, Zhejiang, Peoples R China

[4] Zhejiang Univ, Shaoxing Hosp 2, Shaoxing 312000, Zhejiang, Peoples R China

来源：

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2014年 / 7卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Adipose-derived stem cells; Heart disease; Myocardial infarction; Mesenchymal stem cells; STROMAL-VASCULAR FRACTION; RESTORE CARDIAC-FUNCTION; HEPATOCYTE GROWTH-FACTOR; MESENCHYMAL STEM; MYOCARDIAL-INFARCTION; BONE-MARROW; ISCHEMIC CARDIOMYOPATHY; PROGENITOR CELLS; INTERNATIONAL-SOCIETY; REGENERATIVE CELLS;

D O I：

10.1007/s12265-014-9585-1

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Therapy with mesenchymal stem cells is one of the promising tools to improve outcomes after myocardial infarction. Adipose-derived stem cells (ASCs) are an ideal source of mesenchymal stem cells due to their abundance and ease of preparation. Studies in animal models of myocardial infarction have demonstrated the ability of injected ASCs to engraft and differentiate into cardiomyocytes and vasculature cells. ASCs secrete a wide array of angiogenic and anti-apoptotic paracrine factors such as vascular endothelial growth factor, hepatocyte growth factor, and insulin-like growth factor 1. ASCs are capable of enhancing heart function, reducing myocardial infarction, promoting vascularization, and reversing remodeling in the ischemically injured hearts. Furthermore, several ongoing clinical trials using ASCs are producing promising results for heart diseases. This article reviews the isolation, differentiation, immunoregulatory properties, mechanisms of action, animal models, and ongoing clinical trials of ASCs for cardiac disease.

引用

页码：651 / 663

页数：13

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