Extensive selection for the enrichment of G4 DNA motifs in transcriptional regulatory regions of warm blooded animals

被引：66

作者：

Zhao, Yiqiang ^{[1
]}

Du, Zhuo ^{[1
]}

Li, Ning ^{[1
]}

机构：

[1] China Agr Univ, State Key Lab Agrobiotechnol, Beijing 10094, Peoples R China

来源：

FEBS LETTERS | 2007年 / 581卷 / 10期

基金：

中国国家自然科学基金;

关键词：

G-quadruplex; G4; DNA; transcription; transcription start site; transcriptional regulatory region; warm-blooded animal;

D O I：

10.1016/j.febslet.2007.04.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A comprehensive analysis of potential G4 DNA motifs (G4Ms) in genomic regions flanking transcription start sites (TSS) was performed across 13 animal species. We found that G4Ms are significantly enriched in the transcriptional regulatory regions (TRRs) of warm-blooded animals. Further analysis of human genes in different temporal groups reveals that the enrichment is not specific to genes found only in warm-blooded species but instead exist in a wide range of genes. Our findings therefore suggest that the high prevalence of G4Ms in TRRs is extensively selected in warm-blooded animals, supporting the hypothesis that G4Ms are involved in the regulation of gene transcription. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1951 / 1956

页数：6

共 30 条

[1] Quadruplex DNA: sequence, topology and structure [J].

Burge, Sarah ;

Parkinson, Gary N. ;

Hazel, Pascale ;

Todd, Alan K. ;

Neidle, Stephen .

NUCLEIC ACIDS RESEARCH, 2006, 34 (19) :5402-5415

[2] G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription [J].

Cogoi, Susanna ;

Xodo, Luigi E. .

NUCLEIC ACIDS RESEARCH, 2006, 34 (09) :2536-2549

[3] NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region [J].

Dai, Jixun ;

Chen, Ding ;

Jones, Roger A. ;

Hurley, Laurence H. ;

Yang, Danzhou .

NUCLEIC ACIDS RESEARCH, 2006, 34 (18) :5133-5144

[4] Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2 P1 promoter [J].

Dexheimer, TS ;

Sun, D ;

Hurley, LH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (16) :5404-5415

[5] Enrichment of G4 DNA motif in transcriptional regulatory region of chicken genome [J].

Du, Zhuo ;

Kong, Ping ;

Gao, Yu ;

Li, Ning .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 354 (04) :1067-1070

[6] Gene function correlates with potential for G4 DNA formation in the human genome [J].

Eddy, Johanna ;

Maizels, Nancy .

NUCLEIC ACIDS RESEARCH, 2006, 34 (14) :3887-3896

[7] A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene [J].

Fernando, Himesh ;

Reszka, Anthony P. ;

Huppert, Julian ;

Ladame, Sylvain ;

Rankin, Sarah ;

Venkitaraman, Ashok R. ;

Neidle, Stephen ;

Balasubramanian, Shankar .

BIOCHEMISTRY, 2006, 45 (25) :7854-7860

[8] Expression profiling in primates reveals a rapid evolution of human transcription factors [J].

Gilad, Y ;

Oshlack, A ;

Smyth, GK ;

Speed, TP ;

White, KP .

NATURE, 2006, 440 (7081) :242-245

[9] RETRACTED: Mutations in the G-quadruplex silencer element and their relationship to c-MYC overexpression, NM23 repression, and therapeutic rescue (Retracted Article. See vol 102, pg 516, 2005) [J].

Grand, CL ;

Powell, TJ ;

Nagle, RB ;

Bearss, DJ ;

Tye, D ;

Gleason-Guzman, M ;

Hurley, LH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (16) :6140-6145

[10] G-quadruplex DNA: a potential target for anti-cancer drug design [J].

Han, HY ;

Hurley, LH .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2000, 21 (04) :136-142

← 1 2 3 →