Extensive selection for the enrichment of G4 DNA motifs in transcriptional regulatory regions of warm blooded animals

被引：67

作者：

Zhao, Yiqiang ^{[1
]}

Du, Zhuo ^{[1
]}

Li, Ning ^{[1
]}

机构：

[1] China Agr Univ, State Key Lab Agrobiotechnol, Beijing 10094, Peoples R China

来源：

FEBS LETTERS | 2007年 / 581卷 / 10期

基金：

中国国家自然科学基金;

关键词：

G-quadruplex; G4; DNA; transcription; transcription start site; transcriptional regulatory region; warm-blooded animal;

D O I：

10.1016/j.febslet.2007.04.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A comprehensive analysis of potential G4 DNA motifs (G4Ms) in genomic regions flanking transcription start sites (TSS) was performed across 13 animal species. We found that G4Ms are significantly enriched in the transcriptional regulatory regions (TRRs) of warm-blooded animals. Further analysis of human genes in different temporal groups reveals that the enrichment is not specific to genes found only in warm-blooded species but instead exist in a wide range of genes. Our findings therefore suggest that the high prevalence of G4Ms in TRRs is extensively selected in warm-blooded animals, supporting the hypothesis that G4Ms are involved in the regulation of gene transcription. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1951 / 1956

页数：6

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