Complement-related serine proteases in tunicates and vertebrates

被引:62
作者
Matsushita, M
Endo, Y
Nonaka, M
Fujita, T
机构
[1] Fukushima Med Coll, Dept Biochem, Fukushima 96012, Japan
[2] Nagoya City Univ, Sch Med, Dept Biochem, Mizuho Ku, Nagoya, Aichi 467, Japan
关键词
D O I
10.1016/S0952-7915(98)80027-7
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Serum mannose-binding lectin binds to pathogens in association with a serine protease termed MASP, and in this form, plays a crucial role in innate immunity by activating complement in a manner similar to activation via the classical pathway. MASP, Clr and Cls belong to the same family of serine proteases. In addition to its presence in advanced species, MASP also exists in primitive life forms such as tunicates and may be an evolutionary prototype of this family.
引用
收藏
页码:29 / 35
页数:7
相关论文
共 42 条
[1]   COMPLEMENT-DEPENDENT NEUTRALIZATION OF INFLUENZA-VIRUS BY A SERUM MANNOSE-BINDING LECTIN [J].
ANDERS, EM ;
HARTLEY, CA ;
READING, PC ;
EZEKOWITZ, RAB .
JOURNAL OF GENERAL VIROLOGY, 1994, 75 :615-622
[2]   Exon structure of the gene encoding the human mannose-binding protein-associated serine protease light chain: Comparison with complement C1r and C1s genes [J].
Endo, Y ;
Sato, T ;
Matsushita, M ;
Fujita, T .
INTERNATIONAL IMMUNOLOGY, 1996, 8 (09) :1355-1358
[3]   The collectins in innate immunity [J].
Epstein, J ;
Eichbaum, Q ;
Sheriff, S ;
Ezekowitz, RAB .
CURRENT OPINION IN IMMUNOLOGY, 1996, 8 (01) :29-35
[4]   A HUMAN MANNOSE-BINDING PROTEIN IS AN ACUTE-PHASE REACTANT THAT SHARES SEQUENCE HOMOLOGY WITH OTHER VERTEBRATE LECTINS [J].
EZEKOWITZ, RAB ;
DAY, LE ;
HERMAN, GA .
JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 167 (03) :1034-1046
[5]   MANNOSE-BINDING PROTEIN RECOGNIZES GLIOMA-CELLS - IN-VITRO ANALYSIS OF COMPLEMENT ACTIVATION ON GLIOMA-CELLS VIA THE LECTIN PATHWAY [J].
FUJITA, T ;
TAIRA, S ;
KODAMA, N ;
MATSUSHITA, M ;
FUJITA, T .
JAPANESE JOURNAL OF CANCER RESEARCH, 1995, 86 (02) :187-192
[6]   Susceptibility to HIV infection and progression of AIDS in relation to variant alleles of mannose-binding lectin [J].
Garred, P ;
Madsen, HO ;
Balslev, U ;
Hofmann, B ;
Pedersen, C ;
Gerstoft, J ;
Svejgaard, A .
LANCET, 1997, 349 (9047) :236-240
[7]  
IHARA I, 1982, J IMMUNOL, V128, P1256
[8]  
IKEDA K, 1987, J BIOL CHEM, V262, P7451
[9]   Ancient origin of the complement lectin pathway revealed by molecular cloning of mannan binding: Protein-associated serine protease from a urochordate, the Japanese ascidian, Halocynthia roretzi [J].
Ji, X ;
Azumi, K ;
Sasaki, M ;
Nonaka, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (12) :6340-6345
[10]  
JI YH, 1993, J IMMUNOL, V150, P571