Complement-related serine proteases in tunicates and vertebrates

被引：62

作者：

Matsushita, M

Endo, Y

Nonaka, M

Fujita, T

机构：

[1] Fukushima Med Coll, Dept Biochem, Fukushima 96012, Japan

[2] Nagoya City Univ, Sch Med, Dept Biochem, Mizuho Ku, Nagoya, Aichi 467, Japan

来源：

CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 01期

关键词：

D O I：

10.1016/S0952-7915(98)80027-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Serum mannose-binding lectin binds to pathogens in association with a serine protease termed MASP, and in this form, plays a crucial role in innate immunity by activating complement in a manner similar to activation via the classical pathway. MASP, Clr and Cls belong to the same family of serine proteases. In addition to its presence in advanced species, MASP also exists in primitive life forms such as tunicates and may be an evolutionary prototype of this family.

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页码：29 / 35

页数：7

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