Microarray platforms for enzymatic and cell-based assays

被引：67

作者：

Diaz-Mochon, Juan J. ^{[1
]}

Tourniaire, Guilhem ^{[1
]}

Bradley, Mark ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Chem, Edinburgh EH9 3JJ, Midlothian, Scotland

来源：

CHEMICAL SOCIETY REVIEWS | 2007年 / 36卷 / 03期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1039/b511848b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This tutorial review introduces the uninitiated to the world of microarrays (or so-called chips) and covers a number of basic concepts such as substrates and surfaces, printing and analysis. It then moves on to look at some newer applications of microarray technology, which include enzyme analysis (notably kinases and proteases) as well as the growing enchantment with so-called cell-based microarrays that offer a unique approach to high-throughput cellular analysis. Finally, it looks forwards and highlights future possible trends and directions in the microarray arena.

引用

页码：449 / 457

页数：9

共 44 条

[1] Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells [J].

Anderson, DG ;

Levenberg, S ;

Langer, R .

NATURE BIOTECHNOLOGY, 2004, 22 (07) :863-866

[2] Subnanoliter enzymatic assays on microarrays [J].

Angenendt, P ;

Lehrach, H ;

Kreutzberger, J ;

Glökler, J .

PROTEOMICS, 2005, 5 (02) :420-425

[3] Cell microarrays [J].

Angres, B .

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2005, 5 (05) :769-779

[4] Protein microchips: Use for immunoassay and enzymatic reactions [J].

Arenkov, P ;

Kukhtin, A ;

Gemmell, A ;

Voloshchuk, S ;

Chupeeva, V ;

Mirzabekov, A .

ANALYTICAL BIOCHEMISTRY, 2000, 278 (02) :123-131

[5] Microarrays of small molecules embedded in biodegradable polymers for use in mammalian cell-based screens [J].

Bailey, SN ;

Sabatini, DM ;

Stockwell, BR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (46) :16144-16149

[6] Microarrays of lentiviruses for gene function screens in immortalized and primary cells [J].

Bailey, SN ;

Ali, SM ;

Carpenter, AE ;

Higgins, CO ;

Sabatini, DM .

NATURE METHODS, 2006, 3 (02) :117-122

[7] A novel glass slide-based peptide array support with high functionality resisting non-specific protein adsorption [J].

Beyer, M ;

Felgenhauer, T ;

Bischoff, FR ;

Breitling, F ;

Stadler, V .

BIOMATERIALS, 2006, 27 (18) :3505-3514

[8] Micropatterned surfaces for control of cell shape, position, and function [J].

Chen, CS ;

Mrksich, M ;

Huang, S ;

Whitesides, GM ;

Ingber, DE .

BIOTECHNOLOGY PROGRESS, 1998, 14 (03) :356-363

[9] Proteomic analysis of in vivo phosphorylated synaptic proteins [J].

Collins, MO ;

Yu, L ;

Coba, MP ;

Husi, H ;

Campuzano, L ;

Blackstock, WP ;

Choudhary, JS ;

Grant, SGN .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (07) :5972-5982

[10] Combinatorial libraries -: from solution to 2D microarrays [J].

Díaz-Mochón, JJ ;

Bialy, L ;

Keinicke, L ;

Bradley, M .

CHEMICAL COMMUNICATIONS, 2005, (11) :1384-1386

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