Chiral reagents for the determination of enantiomeric excess and absolute configuration using NMR spectroscopy

被引：293

作者：

Wenzel, TJ ^{[1
]}

Wilcox, JD ^{[1
]}

机构：

[1] Bates Coll, Dept Chem, Lewiston, ME 04240 USA

来源：

CHIRALITY | 2003年 / 15卷 / 03期

关键词：

NMR; chiral shift reagents; enantiomeric excess; absolute configuration; chiral derivatizing agent; chiral solvating agent;

D O I：

10.1002/chir.10190

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Recent advances in the development of chiral derivatizing and solvating agents that facilitate the determination of enantiomeric excess and absolute configuration are reviewed. These include metal-containing species, host-guest systems, donor-acceptor compounds, and liquid crystal discriminating agents. In the aggregate, these reagents can be used to analyze a wide range of compound classes. (C) 2003 Wiley-Liss, Inc.

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页码：256 / 270

页数：15

相关论文

共 145 条

[1]

AKASAKA K, 2000, TENNEN YUKI KAGOBUTS, P565

[2] Optically active palladacycles containing imines derived from 1-(1-naphthyl)ethylamine: new resolving agents for P-chiral phosphines [J].

Albert, J ;

Cadena, JM ;

Granell, JR ;

Solans, X ;

Font-Bardia, M .

TETRAHEDRON-ASYMMETRY, 2000, 11 (09) :1943-1955

[3] Determination of the enantiomeric excess of chiral carboxylic acids by 31P NMR with C2 symmetrical diamines [J].

Alexakis, A ;

Chauvin, AS .

TETRAHEDRON-ASYMMETRY, 2001, 12 (10) :1411-1415

[4] TADDOL organophosphorus derivatising agents for the determination of the enantiomeric excess of chiral alcohols and carboxylic acids by 31P and 1H NMR spectroscopy [J].

Alexakis, A ;

Chauvin, AS .

TETRAHEDRON-ASYMMETRY, 2000, 11 (21) :4245-4248

[5]

Alfonso I, 2001, HELV CHIM ACTA, V84, P280, DOI 10.1002/1522-2675(20010228)84:2<280::AID-HLCA280>3.3.CO

[6]

2-F

[7]

Allenmark S, 2000, ENANTIOMER, V5, P451

[8] Chiral selectors based on C2-symmetric dicarboxylic acids [J].

Allenmark, S ;

Skogsberg, U ;

Thunberg, L .

TETRAHEDRON-ASYMMETRY, 2000, 11 (17) :3527-3534

[9] Preparation of (R)- and (S)-1-adamantyl-9-anthrylmethanol.: Conformational study and their behaviour as chiral solvating agents [J].

Almer, S ;

Cervelló, E ;

Jaime, C ;

Virgili, A .

TETRAHEDRON-ASYMMETRY, 1999, 10 (19) :3719-3725

[10] Determination of the enantiomeric purity and the configuration of β-aminoalcohols using (R)-2-fluorophenylacetic acid (AFPA) and fluorine-19 NMR:: application to β-blockers [J].

Apparu, M ;

Ben Tiba, Y ;

Léo, PM ;

Hamman, S ;

Coulombeau, C .

TETRAHEDRON-ASYMMETRY, 2000, 11 (14) :2885-2898

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