Identification of a novel antiangiogenic agent;: 4-(N-imidazol-2-ylmethyl)amino benzopyran analogues

被引：11

作者：

Kim, N

Lee, S

Yi, KY

Yoo, SE

Kim, G

Lee, CO

Park, SH

Lee, BH

机构：

[1] Korea Res Inst Chem Technol, Div Med Sci, Yoosung Gu, Taejon 305600, South Korea

[2] Chungnam Natl Univ, Dept Chem, Taejon 305764, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(03)00248-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A series of 4-(N-imidazol-2-ylmethyl)aminobenzopyran analogues, originally designed as K-ATP openers for ischemic diseases, showed antiangiogenic properties through the inhibition of HUVEC tube formation. Especially one of p-Cl substituted analogues (4c) completely inhibited HUVEC tube formation at 10 muM. The compound 4c significantly inhibited tumor growth by 52% on A549 (human non small cell lung carcinoma) in nude mice xenografts without any significant side effects. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：1661 / 1663

页数：3

相关论文

共 9 条

[1]

Recent developments in the biology and medicinal chemistry of potassium channel modulators: Update from a decade of progress [J].

Coghlan, MJ ;

Carroll, WA ;

Gopalakrishnan, M .

JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (11) :1627-1653

[2]

A comparison between the effects of BMS-180448, a novel K+ channel opener, and cromakalim in rat and dog [J].

DAlonzo, AJ ;

Darbenzio, RB ;

Sewter, JC ;

Hess, TA ;

Grover, GJ ;

Sleph, PG ;

Normandin, DE ;

Lodge, NJ .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1995, 294 (01) :271-280

[3]

Novel approaches to the treatment of non-small cell lung cancer [J].

Ferreira, CG ;

Huisman, C ;

Giaccone, G .

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2002, 41 (01) :57-77

[4]

Small molecule inhibitors of tumor-promoted angiogenesis, including protein tyrosine kinase inhibitors [J].

Hamby, JM ;

Showalter, HDH .

PHARMACOLOGY & THERAPEUTICS, 1999, 82 (2-3) :169-193

[5]

Angiogenesis: regulators and clinical applications [J].

Liekens, S ;

De Clercq, E ;

Neyts, J .

BIOCHEMICAL PHARMACOLOGY, 2001, 61 (03) :253-270

[6]

Cardioselective antiischemic ATP-sensitive potassium channel (K-ATP) openers .5. Identification of 4-(N-aryl)-substituted benzopyran derivatives with high selectivity [J].

Rovnyak, GC ;

Ahmed, SZ ;

Ding, CZ ;

Dzwonczyk, S ;

Ferrara, FN ;

Humphreys, WG ;

Grover, GJ ;

Santafianos, D ;

Atwal, KS ;

Baird, AJ ;

McLaughlin, LG ;

Normandin, DE ;

Sleph, PG ;

Traeger, SC .

JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (01) :24-34

[7]

Angiogenesis in ischemic and neoplastic disorders [J].

Semenza, GL .

ANNUAL REVIEW OF MEDICINE, 2003, 54 :17-28

[8]

Antiangiogenic agents targeting vascular endothelial growth factor and its receptors in clinical development [J].

Sepp-Lorenzino, L ;

Thomas, KA .

EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2002, 11 (10) :1447-1465

[9]

A novel anti-ischemic ATP-sensitive potassium channel (KATP) opener without vasorelaxation:: N-(6-aminobenzopyranyl)-N′-benzyl-N"-cyanoguanidine analogue [J].

Yoo, S ;

Yi, KY ;

Lee, S ;

Suh, J ;

Kim, N ;

Lee, BH ;

Seo, HW ;

Kim, SO ;

Lee, DH ;

Lim, H ;

Shin, HS .

JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (24) :4207-4215