Effect of temperature on 5-endo- and 4-exo-trig radical cyclizations of N-vinylic α-halo amides

被引：52

作者：

Ishibashi, H

Higuchi, M

Ohba, M

Ikeda, M

机构：

[1] Kanazawa Univ, Fac Pharmaceut Sci, Kanazawa, Ishikawa 920, Japan

[2] Kyoto Pharmaceut Univ, Kyoto 607, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 1-2期

关键词：

D O I：

10.1016/S0040-4039(97)10492-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The radical 3a generated from N-vinylic trichloroacetamide la provided the 5-endo-trig cyclization product 2a in boiling toluene, whereas, at room temperature, gave the 4-exo-trig cyclization product 9. The results may be explained in terms of the reversibility of 4-exo cyclization. (C) 1997 Elsevier Science Ltd. All rights reserved.

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页码：75 / 78

页数：4

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