Translation and protein synthesis: Macrolides

被引：142

作者：

Katz, L ^{[1
]}

Ashley, GW ^{[1
]}

机构：

[1] Kosan Biosci Inc, Hayward, CA 94545 USA

来源：

CHEMICAL REVIEWS | 2005年 / 105卷 / 02期

关键词：

D O I：

10.1021/cr030107f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Macrolides, or macrolactone glycoside antibiotics, act as antibiotics by binding to ribosomes and consequently blocking protein synthesis. The high affinity to bacterial ribosomes, together with the highly conserved structure of ribosomes across virtually all of the bacterial families, give macrolides broad-spectrum activity. This paper describes macrolides by focusing on their classes, clinical uses, modes of action, resistance, and biosynthesis. It also introduces new macrolides and ketolides.

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页码：499 / 527

页数：29

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