Translation and protein synthesis: Macrolides

被引：142

作者：

Katz, L ^{[1
]}

Ashley, GW ^{[1
]}

机构：

[1] Kosan Biosci Inc, Hayward, CA 94545 USA

来源：

CHEMICAL REVIEWS | 2005年 / 105卷 / 02期

关键词：

D O I：

10.1021/cr030107f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Macrolides, or macrolactone glycoside antibiotics, act as antibiotics by binding to ribosomes and consequently blocking protein synthesis. The high affinity to bacterial ribosomes, together with the highly conserved structure of ribosomes across virtually all of the bacterial families, give macrolides broad-spectrum activity. This paper describes macrolides by focusing on their classes, clinical uses, modes of action, resistance, and biosynthesis. It also introduces new macrolides and ketolides.

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收藏

页码：499 / 527

页数：29

相关论文

共 229 条

[51] Structure of cytochrome P450eryF: Substrate, inhibitors, and model compounds bound in the active site [J].

CuppVickery, JR ;

Poulos, TL .

STEROIDS, 1997, 62 (01) :112-116

[52] STRUCTURE OF CYTOCHROME P450ERYF INVOLVED IN ERYTHROMYCIN BIOSYNTHESIS [J].

CUPPVICKERY, JR ;

POULOS, TL .

NATURE STRUCTURAL BIOLOGY, 1995, 2 (02) :144-153

[53] Mutations in domain II of 23 S rRNA facilitate translation of a 23 S rRNA-encoded pentapeptide conferring erythromycin resistance [J].

Dam, M ;

Douthwaite, S ;

Tenson, T ;

Mankin, AS .

JOURNAL OF MOLECULAR BIOLOGY, 1996, 259 (01) :1-6

[54] INACTIVATION OF ANTIBIOTICS AND THE DISSEMINATION OF RESISTANCE GENES [J].

DAVIES, J .

SCIENCE, 1994, 264 (5157) :375-382

[55] L22 ribosomal protein and effect of its mutation on ribosome resistance to erythromycin [J].

Davydova, N ;

Streltsov, V ;

Wilce, M ;

Liljas, A ;

Garber, M .

JOURNAL OF MOLECULAR BIOLOGY, 2002, 322 (03) :635-644

[56] Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens [J].

Denis, A ;

Agouridas, C ;

Auger, JM ;

Benedetti, Y ;

Bonnefoy, A ;

Bretin, F ;

Chantot, JF ;

Dussarat, A ;

Fromentin, C ;

D'Ambrières, SG ;

Lachaud, S ;

Laurin, P ;

Le Martret, O ;

Loyau, V ;

Tessot, N ;

Pejac, JM ;

Perron, S .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (21) :3075-3080

[57] Synthesis of 6-O-methyl-azithromycin and its ketolide analogue via Beckmann rearrangement of 9(E)-6-O-methyl-erythromycin oxime [J].

Denis, A ;

Agouridas, C .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (18) :2427-2432

[58] AN ERYTHROMYCIN ANALOG PRODUCED BY REPROGRAMMING OF POLYKETIDE SYNTHESIS [J].

DONADIO, S ;

MCALPINE, JB ;

SHELDON, PJ ;

JACKSON, M ;

KATZ, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (15) :7119-7123

[59] MODULAR ORGANIZATION OF GENES REQUIRED FOR COMPLEX POLYKETIDE BIOSYNTHESIS [J].

DONADIO, S ;

STAVER, MJ ;

MCALPINE, JB ;

SWANSON, SJ ;

KATZ, L .

SCIENCE, 1991, 252 (5006) :675-679

[60] Molecular basis of clarithromycin activity against Mycobacterium avium and Mycobacterium smegmatis [J].

Doucet-Populaire, F ;

Capobianco, JO ;

Zakula, D ;

Jarlier, V ;

Goldman, RC .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1998, 41 (02) :179-187

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