Beneficial modulation of the gut microbiota

被引：180

作者：

Walsh, Calum J. ^{[1
,2
]}

Guinane, Caitriona M. ^{[1
]}

O'Toole, Paul W. ^{[2
,3
]}

Cotter, Paul D. ^{[1
,3
]}

机构：

[1] TEAGASC, Food Res Ctr, Fermoy, Cork, Ireland

[2] Natl Univ Ireland Univ Coll Cork, Dept Microbiol, Cork, Ireland

[3] Natl Univ Ireland Univ Coll Cork, Alimentary Pharmabiot Ctr, Cork, Ireland

来源：

FEBS LETTERS | 2014年 / 588卷 / 22期

关键词：

Microbiota; Gut health; Microbial modulation; Faecal microbiota transplantation; Diet; Antimicrobial; INTESTINAL BACTERIAL OVERGROWTH; HUMAN COLONIC MICROBIOTA; LACTIC-ACID BACTERIA; CLOSTRIDIUM-DIFFICILE; INSULIN SENSITIVITY; PROBIOTIC BACTERIA; DIETARY MODULATION; WIDE ASSOCIATION; NARROW-SPECTRUM; DOUBLE-BLIND;

D O I：

10.1016/j.febslet.2014.03.035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human gut microbiota comprises approximately 100 trillion microbial cells and has a significant effect on many aspects of human physiology including metabolism, nutrient absorption and immune function. Disruption of this population has been implicated in many conditions and diseases, including examples such as obesity, inflammatory bowel disease and colorectal cancer that are highlighted in this review. A logical extension of these observations suggests that the manipulation of the gut microbiota can be employed to prevent or treat these conditions. Thus, here we highlight a variety of options, including the use of changes in diet (including the use of prebiotics), antimicrobial-based intervention, probiotics and faecal microbiota transplantation, and discuss their relative merits with respect to modulating the intestinal community in a beneficial way. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：4120 / 4130

页数：11

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