ABC transporters in cancer: more than just drug efflux pumps

被引：855

作者：

Fletcher, Jamie I. ^{[1
]}

Haber, Michelle ^{[1
]}

Henderson, Michelle J. ^{[1
]}

Norris, Murray D. ^{[1
]}

机构：

[1] Univ New S Wales, Lowry Canc Res Ctr, Childrens Canc Inst Australia Med Res, Randwick, NSW 2031, Australia

来源：

NATURE REVIEWS CANCER | 2010年 / 10卷 / 02期

基金：

英国医学研究理事会;

关键词：

MULTIDRUG-RESISTANCE PROTEIN; PLATELET-ACTIVATING-FACTOR; BINDING-CASSETTE TRANSPORTERS; PROSTAGLANDIN E-2 TRANSPORT; ATP-DEPENDENT TRANSPORT; STEM-LIKE CELLS; P-GLYCOPROTEIN; GENE-EXPRESSION; SIDE POPULATION; LEUKEMIA-CELLS;

D O I：

10.1038/nrc2789

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Multidrug transporter proteins are best known for their contributions to chemoresistance through the efflux of anticancer drugs from cancer cells. However, a considerable body of evidence also points to their importance in cancer extending beyond drug transport to fundamental roles in tumour biology. Currently, much of the evidence for these additional roles is correlative and definitive studies are needed to confirm causality. We propose that delineating the precise roles of these transporters in tumorigenesis and treatment response will be important for the development of more effective targeted therapies.

引用

收藏

页码：147 / 156

页数：10

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