Osteoclast progenitors promote bone vascularization and osteogenesis

被引：58

作者：

Kusumbe, Anjali P. ^{[1
]}

Adams, Ralf H.

机构：

[1] Univ Munster, Dept Tissue Morphogenesis, Max Planck Inst Mol Biomed, D-48149 Munster, Germany

来源：

NATURE MEDICINE | 2014年 / 20卷 / 11期

关键词：

MESENCHYMAL STEM-CELLS; SPHINGOSINE; 1-PHOSPHATE; DIFFERENTIATION; ANGIOGENESIS;

D O I：

10.1038/nm.3747

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Preosteoclasts give rise to bone-resorbing osteoclasts, which are crucial for skeletal homeostasis. A study now shows that preosteoclasts also contribute to bone formation by releasing platelet-derived growth factor-BB, which promotes bone vascularization and osteogenesis.

引用

收藏

页码：1238 / 1240

页数：3

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