Organocatalytic asymmetric Friedel-Crafts alkylation/cascade reactions of naphthols and nitroolefins

被引：121

作者：

Liu, Tian-Yu

Cui, Hai-Lei

Chai, Qian

Long, Jun

Li, Bang-Jing

Wu, Yong

Ding, Li-Sheng

Chen, Ying-Chun ^{[1
]}

机构：

[1] Sichuan Univ, Key Lab Drug Targeting Educ Minist, W China Sch Pharm, Chengdu 610041, Peoples R China

[2] Sichuan Univ, Dept Med Chem, W China Sch Pharm, Chengdu 610041, Peoples R China

[3] Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China

[4] Sichuan Univ, State Key Lab Biotherapy, W China Hosp, Chengdu 610064, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2007年 / 22期

关键词：

D O I：

10.1039/b704925k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The asymmetric Michael-type Friedet-Crafts reaction of naphthols and nitroolefins promoted by bifunctional thiourea-tertiary amine organocatalysts (up to 95% ee) was investigated; on simply extending the reaction time further cascade reactions could occur to generate enantiopure dimeric tricyclic 1,2-dihydronaphtho[2,1-b]furanyl-2-hydroxylamine derivatives.

引用

收藏

页码：2228 / 2230

页数：3

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