Novel axially chiral bis-arylthiourea-based organocatalysts for asymmetric Friedel-Crafts type reactions

被引：133

作者：

Fleming, Eimear M. ^{[1
]}

McCabe, Thomas ^{[1
]}

Connon, Stephen J. ^{[1
]}

机构：

[1] Univ Dublin Trinity Coll, Sch Chem, Ctr Synth & Chem Biol, Dublin 2, Ireland

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 39期

关键词：

D O I：

10.1016/j.tetlet.2006.07.112

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

It has been shown that catalytic amounts (10-20 mol %) of novel axially chiral bis-arylthioureas promote the asymmetric organocatalytic Friedel-Crafts type addition of indole and N-methylindole to nitroolefins. The optimum catalyst is capable of promoting the reaction between challenging substrates such as N-methylindole and nitroolefins bearing aliphatic beta-substituents with enantioselectivity unprecedented for an organocatalytic system. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：7037 / 7042

页数：6

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