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Rapid determination of Papaver somniferum alkaloids in process streams using monolithic column high-performance liquid chromatography with chemiluminescence detection

被引：43
作者：
Costin, Jason W.
Lewis, Simon W.
Purcell, Stuart D.
Waddell, Lucy R.
Francis, Paul S.
Barrnett, Neil W. [1 ]
机构：
[1] Deakin Univ, Sch Life & Environm Sci, Geelong, Vic 3217, Australia
[2] Curtin Univ Technol, Dept Appl Chem, Perth, WA 6845, Australia
[3] GlaxoSmithKline Inc, Port Fairy, Vic 3284, Australia
来源：
ANALYTICA CHIMICA ACTA | 2007年 / 597卷 / 01期
关键词：
monolithic column; alkaloids; chemiluminescence;
D O I：
10.1016/j.aca.2007.06.044
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
We have combined high-performance liquid chromatography (HPLC) separations using a monolithic column with acidic potassium permanganate and tris(2,2'-bipyridyl)ruthenium(II) chemiluminescence detection in a rapid and highly sensitive method to monitor the process of extracting opiate alkaloids from Papaver somniferum. Due to the high flow rates allowed with the monolithic column and the inherent selectivity of the chemiluminescence reactions, the four predominant alkaloids - morphine, codeine, oripavine and thebaine - were determined in less than 2 min. The results obtained with numerous process samples compared favourable with those of the standard HPLC methodology. Limits of detection were 1 x 10(-10) M, 5 x 10(-10) M, 5 x 10(-10) M and 1 x 10(-9) M, for morphine, codeine, oripavine and thebaine, respectively. (c) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：19 / 23
页数：5
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