Protein insertion into the inner membrane of mitochondria

被引:57
作者
Herrmann, JM [1 ]
Neupert, W [1 ]
机构
[1] Inst Physiol Chem, D-81377 Munich, Germany
关键词
membrane insertion; mitochondria; protein translocation; Oxa1; Cox18; Mba1; respiratory chain;
D O I
10.1080/1521654031000123349
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The inner membrane of mitochondria harbours a large number of polypeptides, many of which have evolved from proteins of the prokaryotic progenitors of mitochondria. The sorting routes on which these proteins are integrated into the mitochondrial inner membrane reflect their phylogenetic origin: Proteins of eukaryotic descent typically reach their destination following arrest of import at the level of the inner membrane. In contrast, many proteins inherited from the prokaryotic progenitor cell are inserted into the inner membrane in an export step following translocation into the matrix. Recently, three different insertion pathways from the matrix into the inner membrane were identified which show considerable parallels to the protein insertion processes in bacteria and chloroplasts. Two of these pathways depend on the related inner membrane proteins Oxa1 and Cox18. A third route is less well defined and depends on the membrane-associated matrix protein Mba1.
引用
收藏
页码:219 / 225
页数:7
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