IMPs, VIMs and SPMs:: the diversity of metallo-β-lactamases produced by carbapenem-resistant Pseudomonas aeruginosa in a Brazilian hospital

被引：67

作者：

Sader, HS

Reis, AO

Silbert, S

Gales, AC

机构：

[1] Jones Grp, JMI Labs, N Liberty, IA 52317 USA

[2] Univ Fed Sao Paulo, Lab Alerta, Sao Paulo, Brazil

[3] Univ Fed Sao Paulo, Disciplina Doencas Infecciosas & Parasitarias, Lab Especial Microbiol Clin, Sao Paulo, Brazil

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2005年 / 11卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

carbapenem resistance; imipenem resistance; metallo-beta-lactamases; polymyxin; Pseudomonas aeruginosa;

D O I：

10.1111/j.1469-0691.2004.01031.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Pseudomonas aeruginosa isolates (n = 183), collected from bacteraemic patients hospitalised in Sao Paulo Hospital (Brazil) during 2000-2001, were screened for susceptibility to antimicrobial agents. The polymyxins were the most active compounds (100% susceptibility), followed by amikacin and cefepime (59.0%), meropenem (57.4%), and imipenem and gentamicin (55.2%). Imipenem-resistant isolates were ribotyped and screened for production of metallo-beta-lactamases (MBLs) by PCR with primers for bla(IMP), bla(VIM) and bla(SPM). MBL production was detected in 36 isolates (19.7% of the entire collection; 43.9% of the imipenem-resistant isolates) and the MBLs included SPM-1-like (55.6%), VIM-2-like (30.6%) and IMP-1-like (8.3%) enzymes.

引用

页码：73 / 76

页数：5

共 12 条

[11] Molecular characterization of SPM-1, a novel metallo-β-lactamase isolated in Latin America:: report from the SENTRY antimicrobial surveillance programme [J].