Study of the required HLB for the solubilization of cholesterol in aqueous solution

被引：6

作者：

Schulz, PC ^{[1
]}

Moya, S ^{[1
]}

机构：

[1] Univ Nacl Sur, Dept Quim & Ing Qca, RA-8000 Bahia Blanca, Argentina

来源：

COLLOID AND POLYMER SCIENCE | 1998年 / 276卷 / 01期

关键词：

cholesterol; solubilization; HLB; mixed micelles; emulsions; critical micelle concentration;

D O I：

10.1007/s003960050213

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The solubilization of cholesterol by anionic surfactant mixtures was studied as a function of their HLB values. The relationship between the logarithm of the critical micelle concentration and the HLB value of the mixtures was not linear, which was attributed to a lack of strict additivity of the HLB values. The solubilized cholesterol/surfactant ratio was determined and it was found to be higher than that in bile salts in all the studied surfactant mixtures. Below HLB = 24, emulsions were obtained, and the remaining cholesterol was solid. Above that value, limpid solutions were obtained, giving a solubility maximum at HLB approximate to 35. The non-solubilized cholesterol was mainly in the form of lamellar mesophase.

引用

页码：87 / 91

页数：5

共 46 条

[1] PHYSICOCHEMICAL BASIS OF CHOLESTEROL GALLSTONE FORMATION IN MAN [J].

ADMIRAND, WH ;

SMALL, DM .

JOURNAL OF CLINICAL INVESTIGATION, 1968, 47 (05) :1043-&

[2] MISCIBILITY OF DIPALMITOYLPHOSPHATIDYLCHOLINE, OLEIC-ACID AND CHOLESTEROL MEASURED BY DSC AND COMPRESSION ISOTHERMS OF MONOLAYERS [J].

BUSQUETS, MA ;

MESTRES, C ;

ALSINA, MA ;

ANTON, JMG ;

REIG, F .

THERMOCHIMICA ACTA, 1994, 232 (02) :261-269

[3] PHYSICAL-CHEMISTRY OF CHOLESTEROL SOLUBILITY IN BILE - RELATIONSHIP TO GALLSTONE FORMATION AND DISSOLUTION IN MAN [J].

CAREY, MC ;

SMALL, DM .

JOURNAL OF CLINICAL INVESTIGATION, 1978, 61 (04) :998-1026

[4]

CASDORPH HR, 1976, LIPID PHARM, P222

[5] Aggregation behavior of bile salts in aqueous solution [J].

Coello, A ;

Meijide, F ;

Nunez, ER ;

Tato, JV .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1996, 85 (01) :9-15

[6] NUCLEAR MAGNETIC-RESONANCE AND X-RAY STUDIES ON MICELLAR AGGREGATES OF SODIUM DEOXYCHOLATE [J].

CONTE, G ;

DIBLASI, R ;

GIGLIO, E ;

PARRETTA, A ;

PAVEL, NV .

JOURNAL OF PHYSICAL CHEMISTRY, 1984, 88 (23) :5720-5724

[7]

Davies JT., 1961, INTERFACIAL PHENOMEN, DOI 10.1016/B978-0-12-206056-4.X5001-2

[8] COMPACTIN (ML-236B) AND RELATED-COMPOUNDS AS POTENTIAL CHOLESTEROL-LOWERING AGENTS THAT INHIBIT HMG-COA REDUCTASE [J].

ENDO, A .

JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (04) :401-405

[9] SIZE AND SHAPE OF SODIUM DEOXYCHOLATE MICELLAR AGGREGATES [J].

ESPOSITO, G ;

GIGLIO, E ;

PAVEL, NV ;

ZANOBI, A .

JOURNAL OF PHYSICAL CHEMISTRY, 1987, 91 (02) :356-362

[10]

FUMASAKI N, 1994, J PHYS CHEM-US, V98, P11541

← 1 2 3 4 5 →