Structural Variations to the 9-N-Methyladeninium Diterpenoid Hybrid Commonly Isolated from Agelas Sponges

被引：25

作者：

Calcul, Laurent ^{[1
]}

Tenney, Karen ^{[1
]}

Ratnam, Joseline ^{[2
,3
]}

McKerrow, James H. ^{[2
,4
]}

Crews, Phillip ^{[1
]}

机构：

[1] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA

[2] Univ Calif San Francisco, Small Mol Discovery Ctr, San Francisco, CA 94158 USA

[3] Univ Calif San Francisco, Sandler Ctr Basic Res Parasit Dis, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94158 USA

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 2010年 / 63卷 / 06期

关键词：

TRYPANOSOMA-BRUCEI; NAKAMURAI HOSHINO; CLATHRODES; MAURITIANA; DISPAR; CONSTITUENTS; GLYCOLIPIDS; NA; K-ATPASE; METABOLITES; ALKALOIDS;

D O I：

10.1071/CH10036

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Four novel 9-N-methyladeninium diterpenoids, agelasine M (3), 2-oxo-agelasine B (4), gelasine A (5), and gelasine B (6) accompanied by the known-agelasine B (1) and F (2) were isolated from the marine sponge Agelas sp. collected in Papua New Guinea. Compounds 3-6 represent higher unsaturated 9-N-methyladeninium bicyclic diterpenoid derivatives including 5 and 6 as unusual norditerpenoid-agelasines. Their structures were elucidated through detailed physical data analyses and comparison with literature properties. All pure compounds were evaluated for inhibitory activity against Trypanosoma brucei as well as for cytotoxicity against Jurkat cells.

引用

页码：915 / 921

页数：7

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