NGAL: a biomarker of acute kidney injury and other systemic conditions

被引：170

作者：

Soni, Sachin S. ^{[1
,3
,4
]}

Cruz, Dinna ^{[1
,2
]}

Bobek, Ilona ^{[1
]}

Chionh, Chang Yin ^{[1
]}

Nalesso, Federico ^{[1
]}

Lentini, Paolo ^{[1
]}

de Cal, Massimo ^{[1
,2
]}

Corradi, Valentina ^{[1
]}

Virzi, Grazia ^{[1
]}

Ronco, Claudio ^{[1
,2
]}

机构：

[1] San Bortolo Hosp, I-36100 Vicenza, Italy

[2] Int Renal Res Inst, Vicenza, Italy

[3] Mediciti Hosp, Hyderabad, Andhra Pradesh, India

[4] Seth Nandlal Dhoot Hosp, Aurangabad, Maharashtra, India

来源：

INTERNATIONAL UROLOGY AND NEPHROLOGY | 2010年 / 42卷 / 01期

关键词：

Biomarker; Neutrophil gelatinase-associated lipocalin; NGAL; Acute kidney injury; AKI; GELATINASE-ASSOCIATED LIPOCALIN; CONTRAST-INDUCED NEPHROPATHY; HUMAN NEUTROPHIL LIPOCALIN; CRITICALLY-ILL CHILDREN; EARLY URINARY BIOMARKER; DELAYED GRAFT FUNCTION; ACUTE-RENAL-FAILURE; CARDIAC-SURGERY; EARLY MARKER; PROTEIN FAMILY;

D O I：

10.1007/s11255-009-9608-z

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Neutrophil gelatinase-associated lipocalin (NGAL) is a 25 kDa protein belonging to the lipocalin superfamily. It was initially found in activated neutrophils, however, many other cells, like kidney tubular cells, may produce NGAL in response to various insults. Recently, it has been found to have a role in iron metabolism by virtue of its binding with siderophores. It has also been found to have a role in kidney development and tubular regeneration after injury. In experimental studies, it was found to be highly expressed in response to tubular injury. In subsequent clinical studies, urine NGAL has been found to be an early predictor for acute kidney injury (AKI). Newer devices for early bedside detection of NGAL are now available. Since serum creatinine is known to be an inadequate and late marker of AKI, NGAL might soon emerge as a troponin-like early marker for AKI. Recent evidence also suggests its role as a biomarker in a variety of other renal and non-renal conditions.

引用

页码：141 / 150

页数：10

共 71 条

[1] Lipocalins:: unity in diversity [J].

Åkerstrom, B ;

Flower, DR ;

Salier, JP .

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 2000, 1482 (1-2) :1-8

[2] Could neutrophil-gelatinase-associated lipocalin and cystatin c predict the development of contrast-induced nephropathy after percutaneous coronary interventions in patients with stable angina and normal serum creatinine values? [J].

Bachorzewska-Gajewska, H. ;

Malyszko, J. ;

Sitniewska, E. ;

Malyszko, J. S. ;

Pawlak, K. ;

Mysliwiec, M. ;

Lawicki, S. ;

Szmitkowski, M. ;

Dobrzycki, S. .

KIDNEY & BLOOD PRESSURE RESEARCH, 2007, 30 (06) :408-415

[3] Neutrophil-gelatinase-associated lipocalin and renal function after percutaneous coronary interventions [J].

Bachorzewska-Gajewska, H. ;

Malyszko, J. ;

Sitniewska, E. ;

Malyszko, J. S. ;

Dobrzycki, S. .

AMERICAN JOURNAL OF NEPHROLOGY, 2006, 26 (03) :287-292

[4] Urine NGAL predicts severity of acute kidney injury after cardiac surgery: A prospective study [J].

Bennett, Michael ;

Dent, Catherine L. ;

Ma, Qing ;

Dastrala, Sudha ;

Grenier, Frank ;

Workman, Ryan ;

Syed, Hina ;

Ali, Salman ;

Barasch, Jonathan ;

Devarajan, Prasad .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2008, 3 (03) :665-673

[5] Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury [J].

Berger, T ;

Togawa, A ;

Duncan, GS ;

Elia, AJ ;

You-Ten, A ;

Wakeham, A ;

Fong, HEH ;

Cheung, CC ;

Mak, TW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (06) :1834-1839

[6] Neutrophil granule proteins in bronchoalveolar lavage fluid from subjects with subclinical emphysema [J].

Betsuyaku, T ;

Nishimura, M ;

Takeyabu, K ;

Tanino, M ;

Venge, P ;

Xu, SY ;

Kawakami, Y .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1999, 159 (06) :1985-1991

[7] Pathological and prognostic value of urinary neutrophil gelatinase-associated lipocalin in macroproteinuric patients with worsening renal function [J].

Bolignano, Davide ;

Coppolino, Giuseppe ;

Lacquaniti, Antonio ;

Nicocia, Giacomo ;

Buemi, Michele .

KIDNEY & BLOOD PRESSURE RESEARCH, 2008, 31 (04) :274-279

[8] Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) is associated with severity of renal disease in proteinuric patients [J].

Bolignano, Davide ;

Coppolino, Giuseppe ;

Campo, Susanna ;

Aloisi, Carmela ;

Nicocia, Giacomo ;

Frisina, Nicola ;

Buemi, Michele .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2008, 23 (01) :414-416

[9] Neutrophil gelatinase-associated lipocalin in patients with autosomal- dominant polycystic kidney disease [J].

Bolignano, Davide ;

Coppolino, Giuseppe ;

Campo, Susanna ;

Aloisi, Carmela ;

Nicocia, Giacomo ;

Frisina, Nicola ;

Buemi, Michele .

AMERICAN JOURNAL OF NEPHROLOGY, 2007, 27 (04) :373-378

[10] Effect of a Single Intravenous Immunoglobulin Infusion on Neutrophil Gelatinase-Associated Lipocalin Levels in Proteinuric Patients With Normal Renal Function [J].

Bolignano, Davide ;

Coppolino, Giuseppe ;

Aloisi, Carmela ;

Romeo, Adolfo ;

Nicocia, Giacomo ;

Buemi, Michele .

JOURNAL OF INVESTIGATIVE MEDICINE, 2008, 56 (08) :997-1003

← 1 2 3 4 5 6 7 8 →