NGAL: a biomarker of acute kidney injury and other systemic conditions

被引：173

作者：

Soni, Sachin S. ^{[1
,3
,4
]}

Cruz, Dinna ^{[1
,2
]}

Bobek, Ilona ^{[1
]}

Chionh, Chang Yin ^{[1
]}

Nalesso, Federico ^{[1
]}

Lentini, Paolo ^{[1
]}

de Cal, Massimo ^{[1
,2
]}

Corradi, Valentina ^{[1
]}

Virzi, Grazia ^{[1
]}

Ronco, Claudio ^{[1
,2
]}

机构：

[1] San Bortolo Hosp, I-36100 Vicenza, Italy

[2] Int Renal Res Inst, Vicenza, Italy

[3] Mediciti Hosp, Hyderabad, Andhra Pradesh, India

[4] Seth Nandlal Dhoot Hosp, Aurangabad, Maharashtra, India

来源：

INTERNATIONAL UROLOGY AND NEPHROLOGY | 2010年 / 42卷 / 01期

关键词：

Biomarker; Neutrophil gelatinase-associated lipocalin; NGAL; Acute kidney injury; AKI; GELATINASE-ASSOCIATED LIPOCALIN; CONTRAST-INDUCED NEPHROPATHY; HUMAN NEUTROPHIL LIPOCALIN; CRITICALLY-ILL CHILDREN; EARLY URINARY BIOMARKER; DELAYED GRAFT FUNCTION; ACUTE-RENAL-FAILURE; CARDIAC-SURGERY; EARLY MARKER; PROTEIN FAMILY;

D O I：

10.1007/s11255-009-9608-z

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Neutrophil gelatinase-associated lipocalin (NGAL) is a 25 kDa protein belonging to the lipocalin superfamily. It was initially found in activated neutrophils, however, many other cells, like kidney tubular cells, may produce NGAL in response to various insults. Recently, it has been found to have a role in iron metabolism by virtue of its binding with siderophores. It has also been found to have a role in kidney development and tubular regeneration after injury. In experimental studies, it was found to be highly expressed in response to tubular injury. In subsequent clinical studies, urine NGAL has been found to be an early predictor for acute kidney injury (AKI). Newer devices for early bedside detection of NGAL are now available. Since serum creatinine is known to be an inadequate and late marker of AKI, NGAL might soon emerge as a troponin-like early marker for AKI. Recent evidence also suggests its role as a biomarker in a variety of other renal and non-renal conditions.

引用

页码：141 / 150

页数：10

共 71 条

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Zappitelli, Michael ;

Washburn, Kimberly K. ;

Arikan, Ayse A. ;

Loftis, Laura ;

Ma, Qing ;

Devarajan, Prasad ;

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