NGAL: a biomarker of acute kidney injury and other systemic conditions

被引：170

作者：

Soni, Sachin S. ^{[1
,3
,4
]}

Cruz, Dinna ^{[1
,2
]}

Bobek, Ilona ^{[1
]}

Chionh, Chang Yin ^{[1
]}

Nalesso, Federico ^{[1
]}

Lentini, Paolo ^{[1
]}

de Cal, Massimo ^{[1
,2
]}

Corradi, Valentina ^{[1
]}

Virzi, Grazia ^{[1
]}

Ronco, Claudio ^{[1
,2
]}

机构：

[1] San Bortolo Hosp, I-36100 Vicenza, Italy

[2] Int Renal Res Inst, Vicenza, Italy

[3] Mediciti Hosp, Hyderabad, Andhra Pradesh, India

[4] Seth Nandlal Dhoot Hosp, Aurangabad, Maharashtra, India

来源：

INTERNATIONAL UROLOGY AND NEPHROLOGY | 2010年 / 42卷 / 01期

关键词：

Biomarker; Neutrophil gelatinase-associated lipocalin; NGAL; Acute kidney injury; AKI; GELATINASE-ASSOCIATED LIPOCALIN; CONTRAST-INDUCED NEPHROPATHY; HUMAN NEUTROPHIL LIPOCALIN; CRITICALLY-ILL CHILDREN; EARLY URINARY BIOMARKER; DELAYED GRAFT FUNCTION; ACUTE-RENAL-FAILURE; CARDIAC-SURGERY; EARLY MARKER; PROTEIN FAMILY;

D O I：

10.1007/s11255-009-9608-z

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Neutrophil gelatinase-associated lipocalin (NGAL) is a 25 kDa protein belonging to the lipocalin superfamily. It was initially found in activated neutrophils, however, many other cells, like kidney tubular cells, may produce NGAL in response to various insults. Recently, it has been found to have a role in iron metabolism by virtue of its binding with siderophores. It has also been found to have a role in kidney development and tubular regeneration after injury. In experimental studies, it was found to be highly expressed in response to tubular injury. In subsequent clinical studies, urine NGAL has been found to be an early predictor for acute kidney injury (AKI). Newer devices for early bedside detection of NGAL are now available. Since serum creatinine is known to be an inadequate and late marker of AKI, NGAL might soon emerge as a troponin-like early marker for AKI. Recent evidence also suggests its role as a biomarker in a variety of other renal and non-renal conditions.

引用

页码：141 / 150

页数：10

共 71 条

[31] Siderocalin (Lcn 2) also binds carboxymycobactins, potentially defending against mycobacterial infections through iron sequestration [J].

Holmes, MA ;

Paulsene, W ;

Jide, X ;

Ratledge, C ;

Strong, RK .

STRUCTURE, 2005, 13 (01) :29-41

[32] The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake [J].

Hvidberg, V ;

Jacobsen, C ;

Strong, RK ;

Cowland, JB ;

Moestrup, SK ;

Borregaard, N .

FEBS LETTERS, 2005, 579 (03) :773-777

[33] Granulocyte activation markers in induced sputum: Comparison between chronic obstructive pulmonary disease, asthma, and normal subjects [J].

Keatings, VM ;

Barnes, PJ .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1997, 155 (02) :449-453

[34]

KJELDSEN L, 1993, J BIOL CHEM, V268, P10425

[35] Predictors of mortality in elderly patients with acute renal failure in a developing country [J].

Kohli, Harbir Singh ;

Bhat, Ashok ;

Aravindan, A. N. ;

Sud, Kamal ;

Jha, Vivekanand ;

Gupta, Krishan Lal ;

Sakhuja, Vinay .

INTERNATIONAL UROLOGY AND NEPHROLOGY, 2007, 39 (01) :339-344

[36] Urinary cystatin C as an early biomarker of acute kidney injury following adult cardiothoracic surgery [J].

Koyner, Jay L. ;

Bennett, Michael R. ;

Worcester, Elaine M. ;

Ma, Qing ;

Raman, Jai ;

Jeevanandam, Valluvan ;

Kasza, Kristen E. ;

Connor, Michael F. O' ;

Konczal, David J. ;

Trevino, Sharon ;

Devarajan, Prasad ;

Murray, Patrick T. .

KIDNEY INTERNATIONAL, 2008, 74 (08) :1059-1069

[37] Serum neutrophil gelatinase-associated lipocalin as a predictor of organ recovery from delayed graft function after kidney transplantation from donors after cardiac death [J].

Kusaka, Mamoru ;

Kuroyanagi, Yoko ;

Mori, Terumi ;

Nagaoka, Kayuri ;

Sasaki, Hitomi ;

Maruyama, Takahiro ;

Hayakawa, Kunihiro ;

Shiroki, Ryoichi ;

Kurahashi, Hiroki ;

Hoshinaga, Kiyotaka .

CELL TRANSPLANTATION, 2008, 17 (1-2) :129-134

[38] Urinary NGAL in premature infants [J].

Lavery, Adrian P. ;

Meinzen-Derr, Jareen K. ;

Anderson, Edward ;

Ma, Qing ;

Bennett, Michael R. ;

Devarajan, Prasad ;

Schibler, Kurt R. .

PEDIATRIC RESEARCH, 2008, 64 (04) :423-428

[39] Comparison between early and delayed acute kidney injury secondary to infectious disease in the intensive care unit [J].

Lima, Rafael S. A. ;

Marques, Cristina N. ;

Silva Junior, Geraldo B. ;

Barbosa, Aline S. ;

Barbosa, Eveline S. ;

Mota, Rosa M. S. ;

Araujo, Sonia M. H. A. ;

Gutierrez-Adrianzen, Oswaldo A. ;

Liborio, Alexandre B. ;

Daher, Elizabeth F. .

INTERNATIONAL UROLOGY AND NEPHROLOGY, 2008, 40 (03) :731-739

[40] IDENTIFICATION OF A NEW ACUTE-PHASE PROTEIN [J].

LIU, QS ;

NILSENHAMILTON, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (38) :22565-22570

← 1 2 3 4 5 6 7 8 →