Distribution of olfactory receptor genes in the human genome

被引：172

作者：

Rouquier, S

Taviaux, S

Trask, BJ

Brand-Arpon, V

van den Engh, G

Demaille, J

Giorgi, D

机构：

[1] CNRS, CRBM, F-34293 Montpellier 5, France

[2] Univ Washington, Dept Mol Biotechnol, Seattle, WA 98195 USA

来源：

NATURE GENETICS | 1998年 / 18卷 / 03期

关键词：

D O I：

10.1038/ng0398-243

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We demonstrate that members of the olfactory receptor (OR) gene family are distributed on all but a few human chromosomes. Through FISH analysis, we show that OR sequences reside at move than 25 locations in the human genome. Their distribution is biased for terminal bands. Flow-sorted chromosomes were used to isolate 87 OR sequences derived from 16 chromosomes. Their sequence-relationships are indicative of the inter- and intrachromosomal duplications responsible for OR family expansion. The human genome has accumulated a striking number of dysfunctional copies: 72% of the sequences are pseudogenes. ORF-containing sequences predominate on chromosomes 7, 16 and 17.

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页码：243 / 250

页数：8

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