The Chemical Compositions of Angelica pubescens Oil and Its Prevention of UV-B Radiation-Induced Cutaneous Photoaging

被引：34

作者：

Chen, Dingkang ^{[1
]}

Du, Zhiyun ^{[1
]}

Lin, Zhirong ^{[1
]}

Su, Ping ^{[1
]}

Huang, Hanyi ^{[1
]}

Ou, Zhirong ^{[1
]}

Pan, Wanyi ^{[1
]}

Huang, Shiya ^{[1
]}

Zhang, Kun ^{[2
]}

Zheng, Xi ^{[3
]}

Lin, Li ^{[4
]}

Zhang, Lanyue ^{[1
]}

机构：

[1] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Inst Nat Med & Green Chem, Guangzhou 510006, Guangdong, Peoples R China

[2] Wuyi Univ, Sch Chem & Environm Engn, Jiangmen 529020, Peoples R China

[3] Rutgers State Univ, Susan Lehman Cullman Lab Canc Res, Ernest Mario Sch Pharm, Dept Biol Chem, 164 Frelinghuysen Rd, Piscataway, NJ 08854 USA

[4] Allan Conney Biotechnol Co Ltd, Foshan 528200, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2018年 / 15卷 / 10期

关键词：

Angelica pubescens; essential oils; skin photoaging; phytoconstituents; ultraviolet radiation; SKIN; LIPOPOLYSACCHARIDE; MECHANISMS; EUGENOL; INFLAMMATION; MACROPHAGES; MICE;

D O I：

10.1002/cbdv.201800235

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Angelica pubescens, a plant of the family Umbelliferae, has been widely used as traditional Chinese medicine for the treatment of many diseases. However, there has been minimal modern research focused on the pharmacological activity of oils extracted from Angelica pubescens, in particular, the potential anti-photoaging effects. Therefore, in the present study, we analyzed the chemical composition of Angelica pubescens oil (AO) and evaluated its bioactivity against photoaging in ultraviolet (UV) -B radiation-induced hairless mice. Overall, we identified and analyzed 93 compounds from the AO by gas chromatography-mass spectrometry (GC/MS). The top ten compounds were as follows: osthole (44.608%), glutaric acid hexadecyl pent-4-en-1-yl ester (5.758%), -bisabolol (3.795%), eugenol (3.637%), (Z)-docos-13-enamide (3.286%), (3S,3aR)-3-butyl-3a,4,5,6-tetrahydro-3H-2-benzofuran-1-one (3.043%), m-cresol (2.841%), trans-sesquisabinene hydrate (2.128%), 4-hydroxy-2-methylacetophenone (1.735%), and (Z)-9-pentadecenol (1.509%). Application of AO improved the condition of UV-B radiation-induced damaged skin, and the mechanism of action was found to be related to inhibition of the production of inflammatory cytokines. These results highlight the potential application of AO for the development of skin care products.

引用

页数：10

共 32 条

[1]

Protective effects of osthole against inflammation induced by lipopolysaccharide in BV2 cells [J].