Toxicity, pharmacokinetics, and in vivo efficacy of biotinylated chitosan surface-modified PLGA nanoparticles for tumor therapy

被引：24

作者：

Chen, Hongli ^{[1
]}

Nan, WenBin ^{[1
]}

Wei, Xiangjuan ^{[1
]}

Wang, Yan ^{[1
]}

Lv, Feng ^{[2
]}

Tang, Hongbo ^{[3
]}

Li, Yonghai ^{[1
]}

Zhou, Chenyan ^{[1
]}

Lin, Juntang ^{[1
]}

Zhu, Wuling ^{[1
]}

Zhang, Qiqing ^{[2
]}

机构：

[1] Xinxiang Med Univ, Sch Life Sci & Technol, Res Ctr Stem Cell & Biotherapy Technol, 601 Jinsui Rd, Xinxiang 453003, Peoples R China

[2] Chinese Acad Med Sci, Inst Biomed Engn, Tianjin, Peoples R China

[3] Capital Med Univ, Beijing Obstet & Gynecol Hosp, Dept Pharm, Beijing, Peoples R China

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2017年 / 45卷 / 06期

关键词：

Biotin; chitosan; pharmacokinetics; PLGA nanoparticle; toxicity; tumor; VITRO; DOXORUBICIN; EPIRUBICIN; DELIVERY; RELEASE;

D O I：

10.1080/21691401.2016.1202260

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Based on our previous work on the PLGA nanoparticles modified with biotinylated chitosan (Bio-CS-PLGA NPs), we further studied the stability, toxicity, pharmacokinetics, and in vivo efficacy. The safety of NPs was studied through single-dose toxicity test in mice, and the result showed that NPs were well tolerated at the dose of 300 mg/kg. Compared with the free EPB group, the NPs group exhibited higher plasma drug concentration, longer half-life time. EPB-loaded NPs significantly inhibited the tumor growth compared to free EPB. All results suggested that Bio-CS-PLGA NPs were stable, safe, and showed a promising potential on targeted drug delivery.

引用

收藏

页码：1115 / 1122

页数：8

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