Cardiovascular complications of diabetes mellitus: The Tissue Factor perspective

被引：27

作者：

Bogdanov, Vladimir Y. ^{[2
]}

Osterud, Bjarne ^{[1
]}

机构：

[1] Univ Tromso, Inst Med Biol, Dept Biochem, N-9037 Tromso, Norway

[2] Univ Cincinnati, Coll Med, Div Hematol Oncol, Cincinnati, OH USA

来源：

THROMBOSIS RESEARCH | 2010年 / 125卷 / 02期

关键词：

Tissue Factor; diabetes; cardiovascular complications; FACTOR PROCOAGULANT ACTIVITY; ENDOTHELIAL GROWTH-FACTOR; MONOCYTE-DERIVED MICROPARTICLES; ACUTE MYOCARDIAL-INFARCTION; FACTOR PATHWAY INHIBITOR; FACTOR EXPRESSION; WHOLE-BLOOD; P-SELECTIN; STIMULATED MONOCYTES; THROMBIN GENERATION;

D O I：

10.1016/j.thromres.2009.06.033

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heightened activity of circulating Tissue Factor (TF) has been linked to a variety of macro-and microvascular cardiovascular complications commonly observed in diabetes mellitus. Systemic and localized vascular abnormalities comprise the most debilitating feature of diabetic pathophysiology. Blood monocytes are chronically activated in diabetes, and serve as the major source of bioactive intravascular TF. This review examines recent literature on this subject, with a special emphasis on the abnormal monocyte physiology in diabetes and the structural and functional diversity of circulating TF. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：112 / 118

页数：7

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