2-substituted benzoxazinone analogues as anti-human coronavirus (anti-HCoV) and ICAM-1 expression inhibition agents

被引：58

作者：

Hsieh, PW

Chang, FR

Chang, CH

Cheng, PW

Chiang, LC

Zeng, FL

Lin, KH

Wu, YC ^{[1
]}

机构：

[1] Kaohsiung Med Univ, Grad Inst Nat Products, Kaohsiung 807, Taiwan

[2] Kaohsiung Med Univ, Dept Ophthalmol, Kaohsiung, Taiwan

[3] Kaohsiung Med Univ, Dept Microbiol, Kaohsiung 807, Taiwan

[4] Kaohsiung Med Univ, Dept Lab Diagnosis, Virol Lab, Kaohsiung 807, Taiwan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 18期

关键词：

benzoxazinones; Anti-HCoVs; ICAM-1;

D O I：

10.1016/j.bmcl.2004.06.083

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A series of 2-substituted benzoxazinones were synthesized and subjected to anti-human coronavirus and ICAM-1 expression inhibition assays. Among them, compounds 1, 3, 4, 5, 6, and 7 exhibited significant anti-HCoV activities, and the IC50 value of these compounds are 6.08, 5.06, 6.83, 1.92, 7.59, and 5.79 mug/mL, respectively. Furthermore, compounds 1 and 6 showed significant inhibitory effect on ICAM-1 expression, the ED50 values of 1 and 6 are 1.00 and 0.50 mug/mL, respectively. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：4751 / 4754

页数：4

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