A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma

被引：421

作者：

Chen, Ruihuan ^{[1
]}

Nishimura, Merry C. ^{[1
]}

Bumbaca, Stephanie M. ^{[1
]}

Kharbanda, Samir ^{[1
]}

Forrest, William F. ^{[2
]}

Kasman, Ian M. ^{[1
]}

Greve, Joan M. ^{[1
]}

Soriano, Robert H. ^{[3
]}

Gilmour, Laurie L. ^{[4
]}

Rivers, Celina Sanchez ^{[3
]}

Modrusan, Zora ^{[3
]}

Nacu, Serban ^{[5
]}

Guerrero, Steve ^{[5
]}

Edgar, Kyle A. ^{[6
]}

Wallin, Jeffrey J. ^{[6
]}

Lamszus, Katrin ^{[7
]}

Westphal, Manfred ^{[7
]}

Heim, Susanne ^{[8
]}

James, C. David ^{[9
]}

VandenBerg, Scott R. ^{[9
]}

Costello, Joseph F. ^{[9
]}

Moorefield, Scott ^{[9
]}

Cowdrey, Cynthia J. ^{[9
]}

Prados, Michael ^{[9
]}

Phillips, Heidi S. ^{[1
,9
]}

机构：

[1] Genentech Inc, Dept Tumor Biol & Angiogenesis, San Francisco, CA 94080 USA

[2] Genentech Inc, Dept Biostat, San Francisco, CA 94080 USA

[3] Genentech Inc, Dept Mol Biol, San Francisco, CA 94080 USA

[4] Genentech Inc, Dept Immunol, San Francisco, CA 94080 USA

[5] Genentech Inc, Dept Bioinformat, San Francisco, CA 94080 USA

[6] Genentech Inc, Dept Canc Signaling, San Francisco, CA 94080 USA

[7] Univ Hamburg Eppendorf, D-20246 Hamburg, Germany

[8] Definiens AG, D-80339 Munich, Germany

[9] Univ Calif San Francisco, Brain Tumor Res Ctr, San Francisco, CA 94143 USA

来源：

CANCER CELL | 2010年 / 17卷 / 04期

基金：

美国国家卫生研究院;

关键词：

CANCER STEM-CELLS; NEURAL STEM/PROGENITOR CELLS; GLIOMA; IDENTIFICATION; PROGENITORS; ASTROCYTES; EXPRESSION; PROGNOSIS; FABP7; PROGRESSION;

D O I：

10.1016/j.ccr.2009.12.049

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The neural stem cell marker CD133 is reported to identify cells within glioblastoma (GBM) that can initiate neurosphere growth and tumor formation; however, instances of CD133(-) cells exhibiting similar properties have also been reported. Here, we show that some PTEN-deficient GBM tumors produce a series of CD133(+) and CD133(-) self-renewing tumor-initiating cell types and provide evidence that these cell types constitute a lineage hierarchy. Our results show that the capacities for self-renewal and tumor initiation in GBM need not be restricted to a uniform population of stemlike cells, but can be shared by a lineage of self-renewing cell types expressing a range of markers of forebrain lineage.

引用

页码：362 / 375

页数：14

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