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GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo

被引：494
作者：
Bustelo, Xose R.
Sauzeau, Vincent
Berenjeno, Inmaculada M.
机构：
[1] Univ Salamanca, Ctr Invest Canc, E-37007 Salamanca, Spain
[2] Univ Salamanca, IBMCC, CSIC, E-37007 Salamanca, Spain
来源：
BIOESSAYS | 2007年 / 29卷 / 04期
关键词：
D O I：
10.1002/bies.20558
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Rho/Rac proteins constitute a subgroup of the Ras superfamily of GTP hydrolases. Although originally implicated in the control of cytoskeletal events, it is currently known that these GTPases coordinate diverse cellular functions, including cell polarity, vesicular trafficking, the cell cycle and transcriptomal dynamics. In this review, we will provide an overview on the recent advances in this field regarding the mechanism of regulation and signaling, and the roles in vivo of this important GTPase family.
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收藏
页码：356 / 370
页数：15
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