Production of antibodies in plants and their use for global health

被引：40

作者：

Fischer, R

Twyman, RM

Schillberg, S

机构：

[1] Fraunhofer Inst Mol Biol & Appl Ecol, IME, D-57393 Schmallenberg, Germany

[2] Rhein Westfal TH Aachen, Inst Mol Biotechnol, D-52074 Aachen, Germany

[3] Univ York, Dept Biol, York YO10 5DD, N Yorkshire, England

来源：

VACCINE | 2003年 / 21卷 / 7-8期

关键词：

recombinant antibody; passive immunity; transgenic plants;

D O I：

10.1016/S0264-410X(02)00607-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recombinant antibodies can be used to diagnose, treat and prevent disease by exploiting their specific antigen-binding activities. A large number of drugs currently in development are recombinant antibodies and most of these are produced in cultured rodent cells. Although such cells produce authentic functional products, they are expensive, difficult to scale-up and may contain human pathogens. Plants represent a cost-effective, convenient and safe alternative production system and are slowly gaining acceptance. Five plant-derived therapeutic recombinant antibodies (plantibodies) are undergoing clinical evaluation, three of which can be used as prophylactics. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：820 / 825

页数：6

共 49 条

[11] Expression and characterization of bispecific single-chain Fv fragments produced in transgenic plants
Fischer, R
Schumann, D
Zimmermann, S
Drossard, J
Sack, M
Schillberg, S
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 262 (03): : 810 - 816
[12] Affinity-purification of a TMV-specific recombinant full-size antibody from a transgenic tobacco suspension culture
Fischer, R
Liao, YC
Drossard, J
[J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1999, 226 (1-2) : 1 - 10
[13] Expression and characterization of bryodin 1 and a bryodin 1-based single-chain immunotoxin from tobacco cell culture
Francisco, JA
Gawlak, SL
Miller, M
Bathe, J
Russell, D
Chace, D
Mixan, B
Zhao, L
Fell, HP
Siegall, CB
[J]. BIOCONJUGATE CHEMISTRY, 1997, 8 (05) : 708 - 713
[14] Functional expression in bacteria and plants of an scFv antibody fragment against tospoviruses
Franconi, A
Roggero, P
Pirazzi, P
Arias, FJ
Desiderio, A
Bitti, O
Pashkoulov, D
Mattei, B
Bracci, L
Masenga, V
Milne, RG
Benvenuto, E
[J]. IMMUNOTECHNOLOGY, 1999, 4 (3-4): : 189 - 201
[15] Antibody engineering at the millennium
Gavilondo, JV
Larrick, JW
[J]. BIOTECHNIQUES, 2000, 29 (01) : 128 - +
[16] Transgenic plants as protein factories
Giddings, G
[J]. CURRENT OPINION IN BIOTECHNOLOGY, 2001, 12 (05) : 450 - 454
[17] Antibody engineering via genetic engineering of the mouse: XenoMouse strains are a vehicle for the facile generation of therapeutic human monoclonal antibodies
Green, LL
[J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1999, 231 (1-2) : 11 - 23
[18] Strategies for selection of antibodies by phage display
Griffiths, AD
Duncan, AR
[J]. CURRENT OPINION IN BIOTECHNOLOGY, 1998, 9 (01) : 102 - 108
[19] Rapid production of single-chain Fv fragments in plants using a potato virus X episomal vector
Hendy, S
Chen, ZC
Barker, H
Cruz, SS
Chapman, S
Torrance, L
Cockburn, W
Whitelam, CC
[J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1999, 231 (1-2) : 137 - 146
[20] PRODUCTION OF ANTIBODIES IN TRANSGENIC PLANTS
HIATT, A
CAFFERKEY, R
BOWDISH, K
[J]. NATURE, 1989, 342 (6245) : 76 - 78

← 1 2 3 4 5 →