Activation of sympathetic outflow by recombinant human interleukin-1 beta in conscious rats

被引:63
作者
Kannan, H
Tanaka, Y
Kunitake, T
Ueta, Y
Hayashida, Y
Yamashita, H
机构
[1] UNIV OCCUPAT & ENVIRONM HLTH, DEPT PHYSIOL, KITAKYUSHU, FUKUOKA 807, JAPAN
[2] UNIV OCCUPAT & ENVIRONM HLTH, DEPT SYST PHYSIOL, KITAKYUSHU, FUKUOKA 807, JAPAN
关键词
kidney; cardiovascular function; autonomic nervous system;
D O I
10.1152/ajpregu.1996.270.2.R479
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The present study was undertaken to determine the effects of interleukin-1 beta (IL-1 beta) on renal sympathetic nerve activity (RSNA), arterial blood pressure (AP), heart rate (HR), and body temperature in conscious rats. Either intravenous or intracerebroventricular administration of IL-1 beta elicited increases in AP, KR, and RSNA accompanied by a rise in body temperature. The maximum changes in AP, KR, and RSNA occurred 10-15 min after intravenous injection of IL-1 beta (100 ng) and 20-25 min after intracerebroventricular injection (5 ng). The responses induced by the intravenous and intracerebroventricular injections lasted for similar to 15-30 min and did not appear when the animals were pretreated with the cyclooxygenase inhibitor indomethacin (10 mg/kg iv). Moreover, intracerebroventricular injection of prostaglandin E(2) (1 pg) produced responses similar to those induced by IL-1 but with shorter latency. Plasma norepinephrine and adrenocorticotropic hormone concentrations were increased after IL-1 beta injection. The results suggested that IL-1 beta augments cardiovascular and sympathetic outflow through the central action of prostaglandin E(2) in conscious rats.
引用
收藏
页码:R479 / R485
页数:7
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