1,3-Disubstituted-imidazo[1,5-a]pyrazines as insulin-like growth-factor-I receptor (IGF-IR) inhibitors

被引：30

作者：

Mulvihill, Mark J. ^{[1
]}

Ji, Qun-Sheng ^{[1
]}

Werner, Doug ^{[1
]}

Beck, Patricia ^{[1
]}

Cesario, Cara ^{[1
]}

Cooke, Andrew ^{[1
]}

Cox, Matthew ^{[1
]}

Crew, Andrew ^{[1
]}

Dong, Hanqing ^{[1
]}

Feng, Lixin ^{[1
]}

Foreman, K. W. ^{[1
]}

Mak, Gilda ^{[1
]}

Nigro, Anthony ^{[1
]}

O'Connor, Matthew ^{[1
]}

Saroglou, Lydia ^{[1
]}

Stolz, Kathryn M. ^{[1
]}

Sujka, Izabela ^{[1
]}

Volk, Brian ^{[1
]}

Weng, Qinghua ^{[1
]}

Wilkes, Robin ^{[1
]}

机构：

[1] OSI Pharmaceut Inc, Farmingdale, NY 11735 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 04期

关键词：

IGF-IR; IR; tyrosine kinase inhibitors; oncology; imidazopyrazines; imidazo[1,5-a]pyrazines; insulin-like growth-factor-I; receptor; insulin receptor;

D O I：

10.1016/j.bmcl.2006.11.016

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1091 / 1097

页数：7

共 52 条

[1] 7-Pyrrolidinyl- and 7-piperidinyl-5-aryl-pyrrolo[2,3-d] pyrimidines -: Potent inhibitors of the tyrosine kinase c-Src [J].

Altmann, E ;

Missbach, M ;

Green, J ;

Susa, M ;

Wagenknecht, HA ;

Widler, L .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (06) :853-856

[2] Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I [J].

Arnold, LD ;

Calderwood, DJ ;

Dixon, RW ;

Johnston, DN ;

Kamens, JS ;

Munschauer, R ;

Rafferty, P ;

Ratnofsky, SE .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (19) :2167-2170

[3] The igf-1 receptor in cancer biology [J].

Baserga, R ;

Peruzzi, F ;

Reiss, K .

INTERNATIONAL JOURNAL OF CANCER, 2003, 107 (06) :873-877

[4]

BECK PA, Patent No. 2006084654

[5] The Protein Data Bank [J].

Berman, HM ;

Westbrook, J ;

Feng, Z ;

Gilliland, G ;

Bhat, TN ;

Weissig, H ;

Shindyalov, IN ;

Bourne, PE .

NUCLEIC ACIDS RESEARCH, 2000, 28 (01) :235-242

[6] Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck II [J].

Burchat, AF ;

Calderwood, DJ ;

Hirst, GC ;

Holman, NJ ;

Johnston, DN ;

Munschauer, R ;

Rafferty, P ;

Tometzki, GB .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (19) :2171-2174

[7] Pyrazolo[3,4-d]pyrimidines containing an extended 3-substituent as potent inhibitors of Lck -: a selectivity insight [J].

Burchat, AF ;

Calderwood, DJ ;

Friedman, MM ;

Hirst, GC ;

Li, BQ ;

Rafferty, P ;

Ritter, K ;

Skinner, BS .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (12) :1687-1690

[8] Pyrrolo[2,3-d]pyrimidines containing diverse N-7 substituents as potent inhibitors of Lck [J].

Calderwood, DJ ;

Johnston, DN ;

Munschauer, R ;

Rafferty, P .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (12) :1683-1686

[9]

Case D.A., 2002, AMBER 7

[10] Treatment of human breast cancer cells with antisense RNA to the type I insulin-like growth factor receptor inhibits cell growth, suppresses tumorigenesis, alters the metastatic potential, and prolongs survival in vivo [J].

Chernicky, CL ;

Yi, LJ ;

Tan, HQ ;

Gan, SU ;

Ilan, J .

CANCER GENE THERAPY, 2000, 7 (03) :384-395

← 1 2 3 4 5 6 →