1,3-Disubstituted-imidazo[1,5-a]pyrazines as insulin-like growth-factor-I receptor (IGF-IR) inhibitors

被引：30

作者：

Mulvihill, Mark J. ^{[1
]}

Ji, Qun-Sheng ^{[1
]}

Werner, Doug ^{[1
]}

Beck, Patricia ^{[1
]}

Cesario, Cara ^{[1
]}

Cooke, Andrew ^{[1
]}

Cox, Matthew ^{[1
]}

Crew, Andrew ^{[1
]}

Dong, Hanqing ^{[1
]}

Feng, Lixin ^{[1
]}

Foreman, K. W. ^{[1
]}

Mak, Gilda ^{[1
]}

Nigro, Anthony ^{[1
]}

O'Connor, Matthew ^{[1
]}

Saroglou, Lydia ^{[1
]}

Stolz, Kathryn M. ^{[1
]}

Sujka, Izabela ^{[1
]}

Volk, Brian ^{[1
]}

Weng, Qinghua ^{[1
]}

Wilkes, Robin ^{[1
]}

机构：

[1] OSI Pharmaceut Inc, Farmingdale, NY 11735 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 04期

关键词：

IGF-IR; IR; tyrosine kinase inhibitors; oncology; imidazopyrazines; imidazo[1,5-a]pyrazines; insulin-like growth-factor-I; receptor; insulin receptor;

D O I：

10.1016/j.bmcl.2006.11.016

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1091 / 1097

页数：7

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