Catalytic multicomponent reactions for the synthesis of N-aryl trisubstituted pyrroles

被引：135

作者：

Galliford, Chris V. ^{[1
]}

Scheidt, Karl A. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 05期

关键词：

D O I：

10.1021/jo0624086

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dirhodium(II) salts efficiently catalyze the three-component assembly reaction of an imine, diazoacetonitrile (DAN), and an activated alkynyl coupling partner to form substituted 1,2-diarylpyrroles in moderate to good yields. The transition-metal-catalyzed decomposition of the diazo compound in the presence of the imine presumably generates a transient azomethine ylide that undergoes cycloaddition with dipolarophiles in a highly convergent manner.

引用

页码：1811 / 1813

页数：3

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