Continuous synthesis of artemisinin-derived medicines

被引：102

作者：

Gilmore, Kerry ^{[1
]}

Kopetzki, Daniel ^{[1
]}

Lee, Ju Weon ^{[2
]}

Horvath, Zoltan ^{[2
]}

McQuade, D. Tyler ^{[1
]}

Seidel-Morgenstern, Andreas ^{[2
,3
]}

Seeberger, Peter H. ^{[1
,4
]}

机构：

[1] Max Planck Inst Colloids & Interfaces, Dept Biomol Syst, D-14476 Potsdam, Germany

[2] Max Planck Inst Dynam Complex Tech Syst, D-39106 Magdeburg, Germany

[3] Otto Von Guericke Univ, Chair Chem Proc Technol, D-39106 Magdeburg, Germany

[4] Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 84期

关键词：

CONTINUOUS-FLOW SYNTHESIS; MULTISTEP SYNTHESIS; NATURAL-PRODUCTS; CHEMISTRY; MALARIA; PURIFICATION; CONVERSION; REDUCTION;

D O I：

10.1039/c4cc05098c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Described is a continuous, divergent synthesis system which is coupled to continuous purification and is capable of producing four anti-malarial APIs. The system is comprised of three linked reaction modules for photooxidation/cyclization, reduction, and derivatization. A fourth module couples the crude reaction stream with continuous purification to yield pure API.

引用

页码：12652 / 12655

页数：4

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