Ex vivo approaches to predicting oral pharmacokinetics in humans

被引：8

作者：

Stewart, BH ^{[1
]}

Wang, Y ^{[1
]}

Surendran, N ^{[1
]}

机构：

[1] Parke Davis Pharmaceut Res, Ann Arbor, MI 48105 USA

来源：

ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 35 | 2000年 / 35卷

关键词：

D O I：

10.1016/S0065-7743(00)35028-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：299 / 307

页数：9

共 96 条

[61]

Obach RS, 1999, DRUG METAB DISPOS, V27, P1350

[62]

Obach RS, 1997, DRUG METAB DISPOS, V25, P1359

[63] Evaluation of dynamic polar molecular surface area as predictor of drug absorption: Comparison with other computational and experimental predictors [J].

Palm, K ;

Luthman, K ;

Ungell, AL ;

Strandlund, G ;

Beigi, F ;

Lundahl, P ;

Artursson, P .

JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (27) :5382-5392

[64] Correlation of drug absorption with molecular surface properties [J].

Palm, K ;

Luthman, K ;

Ungell, AL ;

Strandlund, G ;

Artursson, P .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1996, 85 (01) :32-39

[65] IAM CHROMATOGRAPHY - AN IN-VITRO SCREEN FOR PREDICTING DRUG MEMBRANE-PERMEABILITY [J].

PIDGEON, C ;

ONG, SW ;

LIU, HL ;

QIU, XX ;

PIDGEON, M ;

DANTZIG, AH ;

MUNROE, J ;

HORNBACK, WJ ;

KASHER, JS ;

GLUNZ, L ;

SZCZERBA, T .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (04) :590-594

[66]

PINTO M, 1983, BIOL CELL, V47, P323

[67] Interplay between CYP3A-mediated metabolism and polarized efflux of terfenadine and its metabolites in intestinal epithelial Caco-2 (TC7) cell monolayers [J].

Raeissi, SD ;

Hidalgo, IJ ;

Segura-Aguilar, J ;

Artursson, P .

PHARMACEUTICAL RESEARCH, 1999, 16 (05) :625-632

[68] Effect of some indole derivatives on xenobiotic metabolism and xenobiotic-induced toxicity in cultured rat liver slices [J].

Renwick, AB ;

Mistry, H ;

Barton, PT ;

Mallet, F ;

Price, RJ ;

Beamand, JA ;

Lake, BG .

FOOD AND CHEMICAL TOXICOLOGY, 1999, 37 (06) :609-618

[69]

Rohatagi S, 1997, Am J Ther, V4, P229, DOI 10.1097/00045391-199707000-00003

[70] An integrated method to determine epithelial transport and bioactivity of oral drug candidates in vitro [J].

Rubas, W ;

Cromwell, MEM ;

Mrsny, RJ ;

Ingle, G ;

Elias, KA .

PHARMACEUTICAL RESEARCH, 1996, 13 (01) :23-26

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