Ex vivo approaches to predicting oral pharmacokinetics in humans

被引:8
作者
Stewart, BH [1 ]
Wang, Y [1 ]
Surendran, N [1 ]
机构
[1] Parke Davis Pharmaceut Res, Ann Arbor, MI 48105 USA
来源
ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 35 | 2000年 / 35卷
关键词
D O I
10.1016/S0065-7743(00)35028-X
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:299 / 307
页数:9
相关论文
共 96 条
[91]  
Witherow LE, 1999, J PHARMACOL EXP THER, V290, P58
[92]   Immobilized artificial membranes - Screens for drug membrane interactions [J].
Yang, CY ;
Cai, SJ ;
Liu, HL ;
Pidgeon, C .
ADVANCED DRUG DELIVERY REVIEWS, 1997, 23 (1-3) :229-256
[93]   Correlating partitioning and Caco-2 cell permeability of structurally diverse small molecular weight compounds [J].
Yazdanian, M ;
Glynn, SL ;
Wright, JL ;
Hawi, A .
PHARMACEUTICAL RESEARCH, 1998, 15 (09) :1490-1494
[94]   Effects of cholestyramine and parenteral nutrition on hepatic metabolism of lidocaine: A study using isolated rat liver perfusion [J].
Zaman, N ;
Tam, YK ;
Jewel, LD ;
Coutts, RT .
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, 1996, 20 (05) :349-356
[95]   Characterization of P-glycoprotein mediated transport of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor, across MDR1-MDCK and Caco-2 cell monolayers [J].
Zhang, YC ;
Benet, LZ .
PHARMACEUTICAL RESEARCH, 1998, 15 (10) :1520-1524
[96]   KINETICS OF DIAZEPAM METABOLISM IN RAT HEPATIC MICROSOMES AND HEPATOCYTES AND THEIR USE IN PREDICTING IN-VIVO HEPATIC-CLEARANCE [J].
ZOMORODI, K ;
CARLILE, DJ ;
HOUSTON, JB .
XENOBIOTICA, 1995, 25 (09) :907-916