Application of micromachine techniques to biotechnological research

被引：16

作者：

Murakami, Y ^{[1
]}

Idegami, K ^{[1
]}

Nagai, H ^{[1
]}

Kikuchi, T ^{[1
]}

Morita, Y ^{[1
]}

Yamamura, A ^{[1
]}

Yokoyama, K ^{[1
]}

Tamiya, E ^{[1
]}

机构：

[1] Japan Adv Inst Sci & Technol, Sch Mat Sci, Tatsunokuchi, Ishikawa 9231292, Japan

来源：

MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS | 2000年 / 12卷 / 1-2期

关键词：

multianalyte biosensing chip; micromachine techniques; biotechnological research;

D O I：

10.1016/S0928-4931(00)00160-0

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Novel methods to construct a multianalyte biosensing chip are described. A method is two-step immobilization in which materials are not immobilized directly but indirectly via small support materials. Biomaterials are immobilized on a certain support particle in the first step. The particles are placed or stuck on a chip in the second step. The other method is random fluidic self-assembly of the microsupports for reducing the complication in the second step on the chip. The combination of the methods enables us to immobilize various kinds of biomaterials densely on a chip. The ways to avoid possible problems due to random distribution are discussed. Several examples are also described. (C) 2000 Elsevier Science S.A. All rights reserved.

引用

页码：67 / 70

页数：4

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