Enantioselective synthesis of axially chiral phthalides through cationic [Rh1(H8-binap)]-catalyzed cross alkyne cyclotrimerization

被引：167

作者：

Tanaka, K ^{[1
]}

Nishida, G

Wada, A

Noguchi, K

机构：

[1] Tokyo Univ Agr & Technol, Dept Appl Chem, Grad Sch Engn, Tokyo 1848588, Japan

[2] Tokyo Univ Agr & Technol, Instrumentat Anal Ctr, Tokyo 1848588, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 47期

关键词：

asymmetric catalysis; atropisomerism; biaryls; cyclotrimerization; rhodium;

D O I：

10.1002/anie.200461533

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical equation presented). Easy access to axially chiral phthalides that bear one or two oxymethylene functionalities is provided by an enantioselective cross alkyne cyclotrimerization in the presence of the cationic complex [Rh1{(S)-H8-binap}]+. The axial chirality is introduced during the formation of the benzene ring with high enantioselectivity.

引用

页码：6510 / 6512

页数：3

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[21] Transition metal catalysed synthesis of tetrahydro derivatives of [5]-, [6]- and [7]helicene [J].