Synthesis and antiviral activities of N-9-oxypurine 1,3-dioxolane and 1,3-oxathiolane nucleosides

被引：14

作者：

Nguyen-Ba, N ^{[1
]}

Lee, N ^{[1
]}

Chan, L ^{[1
]}

Zacharie, B ^{[1
]}

机构：

[1] BioChem Pharma Inc, Laval, PQ H7V 4A7, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(00)00452-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two series of 1,3-dioxolanes and 1,3-oxathiolane nucleosides containing N-9-oxypurine were synthesized as potential antiviral agents. These compounds were prepared by reacting the sugar moieties with iodo- or bromotrimethylsilane, followed by treatment with a mixture of sodium hydride and the desired N-hydroxy purine base. The preparation of these N-hydroxybases was also described. No significant antiviral activity was observed against HIV, HBV, HSV-1, HSV-2, or HCMV. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：2223 / 2226

页数：4

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