Phosphatase and feedback regulation of Raf-1 signaling

被引：55

作者：

Dhillon, Amardeep S.

von Kriegsheim, Alex

Grindlay, Joan

Kolch, Walter

机构：

[1] Beatson Inst Canc Res, Signaling & Proteom Grp, Glasgow G61 1BD, Lanark, Scotland

[2] Univ Glasgow, Sir Henry Wellcome Funct Genom Facil, Glasgow G12 8QQ, Lanark, Scotland

来源：

CELL CYCLE | 2007年 / 6卷 / 01期

关键词：

Raf-1; B-Raf; PP1; PP2A; PP5; 14-3-3; dimerization; feedback phosphorylation; signal transduction;

D O I：

10.4161/cc.6.1.3593

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Raf-1 kinase is an effector of Ras GTPases that lies at the apex of the three-tier Raf/MEK/ERK pathway. Raf-1 activation is a complex process that entails two major events-relief of autoinhibition imposed by the regulatory domain and kinase domain activation. Recent studies indicate that the transition of Raf-1 from an active to an inactive state bears similar complexity to the activation process. Both these events require dynamic changes in Raf-1 phosphorylation. Here, we discuss the critical role of phosphatases and feedback phosphorylation during activation and inactivation of Raf-1 signaling.

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页码：3 / 7

页数：5

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