Presence of virulence and fitness gene modules of enterohemorrhagic Escherichia coli in atypical enteropathogenic Escherichia coli O26

被引：26

作者：

Bielaszewska, Martina

Sonntag, Anne-Katharina

Schmidt, M. Alexander

Karch, Helge

机构：

[1] Univ Munster, Inst Hyg, D-48149 Munster, Germany

[2] Univ Munster, Natl Consulting Lab Hemolyt Urem Syndrome, D-48149 Munster, Germany

[3] Univ Munster, Inst Infectiol, Ctr Mol Biol & Inflammat, ZMBE, D-48149 Munster, Germany

来源：

MICROBES AND INFECTION | 2007年 / 9卷 / 07期

关键词：

enterohemorrhagic Escherichia coli O26; Atypical enteropathogenic Escherichia coli O26; Hemolytic-uremic syndrome; O island O122; Locus for enterocyte effacement; Mosaic island; High pathogenicity island;

D O I：

10.1016/j.micinf.2007.03.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Enterohemorrhagic Escherichia coli (EHEC) strains of serogroup O26 cause hemolytic-uremic syndrome (HUS) whereas atypical enteropathogenic E. coli (aEPEC) O26 typically cause uncomplicated diarrhea but have been also isolated from HUS patients. To gain insight into the virulence of aEPEC O26, we compared the presence of O island (OI) 122, which is associated with enhanced virulence in EHEC strains, among aEPEC O26 and EHEC O26 clinical isolates. We also tested these strains for the high pathogenicity island (HPI) which is a fitness island. All 20 aEPEC O26 and 20 EHEC O26 investigated contained virulence genes located within OI-122 (efa1/lifA, nleB, nleE, ent). In both aEPEC O26 and EHEC O26, OI-122 was linked to the locus for enterocyte effacement, forming a mosaic island which was integrated in pheU. Moreover, strains of these two pathotypes shared a conserved HPI. These data support a close relatedness between aEPEC O26 and EHEC O26 and have evolutionary implications. The presence of OI-122 in aEPEC O26 might contribute to their pathogenic potential. (c) 2007 Elsevier Masson SAS. All rights reserved.

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页码：891 / 897

页数：7

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