Antiulcer activity of grape seed extract and procyanidins

被引:270
作者
Saito, M [1 ]
Hosoyama, H [1 ]
Ariga, T [1 ]
Kataoka, S [1 ]
Yamaji, N [1 ]
机构
[1] Kikkoman Foods Inc, Div Res & Dev, Noda, Chiba 278, Japan
关键词
grape seed extract; antiulcer activity; procyanidin; oligomer; radical scavenging activity; HCl/EtOH-induced ulcer;
D O I
10.1021/jf9709156
中图分类号
S [农业科学];
学科分类号
09 ;
摘要
It is known that procyanidins, which are contained in grape seeds, are antioxidative and have certain biological effects. Antiulcer activities of grape seed extracts (GSE-I and GSE-II) and procyanidins were investigated using rats. GSE-I (with low flavanol content), GSE-II (with high flavanol content), and procyanidins at a dose of 200 mg/kg strongly inhibited the stomach mucosal injury induced by 60% ethanol containing 150 mM hydrochloride. This suppressive effect seems dependent on the content of procyanidin oligomers. Procyanidin oligomers (dimers to hexamers) were prepared and studied for their antiulcer activities at a dose of 200 mg/kg. The gastric protective activity of a series of procyanidins increased with the increasing polymerization of catechin units. Oligomers longer than tetramers showed a strong protective effect against gastric mucosal damage. The binding ability of procyanidin oligomers to bovine serum albumin in the acidified solution was strengthened with the increase of molecules. The mechanism of antiulcer activity may be the protection by radical scavenging activity on the stomach surface against radical injury induced by HCl/EtOH solution and the defense action of pracyanidins covering the stomach surface by their strong ability to bind protein.
引用
收藏
页码:1460 / 1464
页数:5
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