Enhancement of the effect of methotrexate on collagen II induced arthritis in mice by nicotinamide

被引：4

作者：

Kröger, H

Hauschild, A

Ohde, M

Thefeld, W

Krüger, D

Bache, K

Ehrlich, W

机构：

[1] Deutsch Rheumaforschungszentrum Berlin, D-10115 Berlin, Germany

[2] Robert Koch Inst, D-13353 Berlin, Germany

[3] Bundesinst Gesundheitlichen Verbraucherschutz & V, D-12277 Berlin, Germany

来源：

INFLAMMATION | 1998年 / 22卷 / 03期

关键词：

D O I：

10.1023/A:1022348132132

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Treatment with a combination of 10 mg/kg i.p. methotrexate and 100 mg/kg i.p. nicotinamide inhibits the development of collagen II induced arthritis in male DBA/1 X B.10(4R) mice, as assessed by the arthritic index and whole blood chemiluminescence. The effect is much more pronounced than with either methotrexate or nicotinamide alone at the same concentrations. Determination of GOT and GPT levels in the blood revealed that the treatment causes no toxic side effects on the liver.

引用

页码：277 / 285

页数：9

共 20 条

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[2]

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[3]

CASH JM, 1994, NEW ENGL J MED, V330, P1368

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