Stereoselective Total Synthesis of (-)-Cleistenolide

被引：19

作者：

Cai, Chao ^{[1
,2
]}

Liu, Jun ^{[1
]}

Du, Yuguo ^{[1
,2
]}

Linhardt, Robert J. ^{[3
,4
,5
]}

机构：

[1] Chinese Acad Sci, Ecoenvironm Sci Res Ctr, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China

[2] Chinese Acad Sci, Grad Univ, Coll Chem & Chem Engn, Beijing 100049, Peoples R China

[3] Rensselaer Polytech Inst, Dept Chem, Troy, NY 12180 USA

[4] Rensselaer Polytech Inst, Dept Biol, Troy, NY 12180 USA

[5] Rensselaer Polytech Inst, Dept Chem & Biol Engn, Troy, NY 12180 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 16期

关键词：

CONSTITUENTS;

D O I：

10.1021/jo101059e

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

A facile stereoselective total synthesis of cleistenolide (1) from the natural chiral template D-arabinose has been achieved in eight steps and 49% overall yield, employing key steps including Wittig olefination, selective 1,3-trans-acetal formation, and modified Yamaguchi esterification.

引用

收藏

页码：5754 / 5756

页数：3

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