The promise of siRNAs for the treatment of influenza

被引：22

作者：

Bennink, JR ^{[1
]}

Palmore, TN ^{[1
]}

机构：

[1] NIAID, NIH, Viral Dis Lab, Bethesda, MD 20892 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2004年 / 10卷 / 12期

关键词：

D O I：

10.1016/j.molmed.2004.10.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Current WHO reports on the Asian avian influenza virus outbreaks are poignant reminders of the potential for the emergence of highly virulent strains of influenza A virus (IAV) and the fact that it remains a scourge on human health. As IAV drifts and shifts its genetic and antigenic composition, it presents an ever-changing challenge for vaccines and antiviral medications. Short-interfering RNAs (siRNAs) are the latest class of potential antiviral therapeutics to be developed. Recent reports using siRNAs in mice suggest that they hold great promise for the prevention and treatment of IAV infections.

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收藏

页码：571 / 574

页数：4

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