Somatic gene targeting in the developing and adult mouse retina

被引：5

作者：

Ashery-Padan, R ^{[1
]}

机构：

[1] Tel Aviv Univ, Sackler Fac Med, Dept Human Genet & Mol Med, Ramat Aviv, Israel

来源：

METHODS | 2002年 / 28卷 / 04期

基金：

以色列科学基金会;

关键词：

conditional knockout; CrelloxP; pax6; gene targeting; retinogenesis;

D O I：

10.1016/S1046-2023(02)00265-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Retinogenesis is a developmental process that is tightly regulated both temporally and spatially and is therefore an excellent model system for studying the molecular and cellular mechanisms of neurogenesis in the central nervous system. Understanding of these events in vivo is greatly facilitated by the availability of mouse mutant models, including those with natural or targeted mutations and those with conditional knockout or forced expression of genes. This article reviews these genetic modifications and their contribution to the study of retinogenesis in mammals, with special emphasis on conditional gene targeting approaches. (C) 2002 Elsevier Science (USA). All rights reserved.

引用

页码：457 / 464

页数：8

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