Studies on pyrrolidinones.: Synthesis of new α-pyridones derivatives

被引：10

作者：

Malecki, N

Houssin, R

Hénichart, JP

Couturier, D

Petra, F

Legentil, L

Rigo, B

机构：

[1] Ecole Hautes Etud Ind, Grp Rech Inhibit Proliferat Cellulaire EA 2692, F-59046 Lille, France

[2] Univ Lille 2, Inst Chim Pharmaceut Albert Lespagnol, Grp Rech Inhibit Proliferat Cellulaire EA 2692, F-59006 Lille, France

[3] Univ Lille 1, Lab Ingn Mol, F-59655 Lille, France

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2003年 / 40卷 / 01期

关键词：

D O I：

10.1002/jhet.5570400105

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dimethyl 7-methoxycarbonylmethyl-5-oxo-1,2,3,5-tetrahydro-indolizine-3,8-dicarboxylate was synthesized starting from methyl pyroglutamate. A study was made of the reactions of this highly functionalized pyridone with ethyl iodide, selenium oxide, isoamyl nitrite and formaldehyde. Literature reports that reaction of 4-(1-carbomethoxypropyl)-5-carbomethoxy-1,6-cyclopentano-2-pyridone with formaldehyde lead to a 95% yield of a monolactone (26) precursor of camptothecin. Our experiments resulted in 15% of this monolactone and 40% of a new dilactone (27).

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页码：45 / 50

页数：6

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